Evidence map›Paper›PMID 39550726›Full record

ReviewMolecular biology reports2024

PinX1 plays multifaceted roles in human cancers: a review and perspectives.

Dian You, Kaiwen Tong, Yuan Li, Ting Zhang, Yongqiang Wu, Ling Wang, Guangming Chen, Xiaoying Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dian YouHuzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China.
Kaiwen TongHuzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China.
Yuan LiHuzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China.
Ting ZhangHuzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China.
Yongqiang WuBotuvac Biotechnology Co., Ltd, Beijing, China.
Ling WangBotuvac Biotechnology Co., Ltd, Beijing, China.
Guangming ChenHuzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China.
Xiaoying ZhangHuzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China. 02809@zjhu.edu.cn.

Funding

Huzhou Municipal Natural Science Foundation of China 2021YZ02National Innovation and Entrepreneurship Training Program for College Students 202310347064Zhejiang Provincial Natural Science Foundation of China LGF22H300007
6 · The paper itself

Abstract

backgroundPin2/TRF1 interacting protein X1 (PinX1), a telomerase inhibitor, is located at human chromosome 8p23. This region is important for telomere length maintenance and chromosome stability, both of which are essential for regulating human ageing and associated diseases. METHODS AND

resultsWe investigated the research progress of PinX1 in human cancers. In cancers, the expression levels of PinX1 mRNA and protein vary according to cancer cell types, and PinX1 plays a critical role in the regulation of cancer development and progression. Additionally, a review of the literature indicates that PinX1 is involved in mitosis and affects the sensitivity of cancer cells to radiation-induced DNA damage. Therefore, PinX1 has therapeutic potential for cancer, and understanding the function of PinX1 in the regulation of cancers is crucial for improving treatment. In this review, we discuss the expression level of PinX1 in a variety of cancers and how it affects the implicated pathways. Additionally, we outline the function of PinX1 in cancer cells and provide a theoretical basis for PinX1-related cancer therapy.

conclusionsPinX1 has promising prospects in future cancer therapeutics. This review may provide theoretical support for researchers in this field.

Indexed as

Cell Cycle ProteinsNeoplasmsTumor Suppressor ProteinsDNA DamageGene Expression Regulation, NeoplasticHumansMitosisCell Cycle ProteinsPINX1 protein, humanTumor Suppressor ProteinsCancerFunctionMolecular mechanismPinX1Telomerase

Identifiers

PMID39550726
PMCPMC11570563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.