Evidence map›Paper›PMID 39549910›Full record

ArticleEnvironmental research2025

Examining disparities in PFAS plasma concentrations: Impact of drinking water contamination, food access, proximity to industrial facilities and superfund sites.

Shiwen Li, Jesse A Goodrich, Elizabeth Costello, Douglas I Walker, Carlos Cardenas-Iniguez, Jiawen Carmen Chen, Tanya L Alderete, Damaskini Valvi, Sarah Rock, Sandrah P Eckel and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Shiwen LiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: shiwenli@usc.edu.
Jesse A GoodrichDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Elizabeth CostelloDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Douglas I WalkerDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Carlos Cardenas-IniguezDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Jiawen Carmen ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Tanya L AldereteDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Damaskini ValviDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Sarah RockDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Frank D GillilandDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
John WilsonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States; Spatial Sciences Institute, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, Los Angeles, CA, United States; Department of Sociology, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, Los Angeles, CA, United States; School of Architecture, University of Southern California, CA, United States; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA, United States.
Beau MacDonaldSpatial Sciences Institute, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, Los Angeles, CA, United States.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Adam L SmithSonny Astani Department of Civil and Environmental Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA, United States.
Daniel L McCurrySonny Astani Department of Civil and Environmental Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA, United States.
Amy E ChildressSonny Astani Department of Civil and Environmental Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA, United States.
Adam M-A SimpsonSonny Astani Department of Civil and Environmental Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA, United States.
Lucy Golden-MasonDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Ana C Maretti-MiraDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Michael I GoranDepartment of Pediatrics, Children's Hospital Los Angeles, Saban Research Institute, Los Angeles, CA, United States.
Max AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AVOL, EDWARD · 2002 to 2011
$30.2M
TYPE 2 DIABETES IN HISPANIC ADOLESCENTSR01DK059211 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2000 to 2013
$9.2M
Southern California Children's Environmental Health Center (SC-CEHC)P01ES022845 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HRICKO, ANDREA M · 2013 to 2018
$4.0M
Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in YouthR01ES029944 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2023
$3.1M
NIDDK NIH HHS R01 DK059211NIEHS NIH HHS P01 ES011627NIEHS NIH HHS P01 ES022845NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES029944
6 · The paper itself

Abstract

backgroundMost of the US population is exposed to per- and polyfluorinated substances (PFAS) through various environmental media and these sources of PFAS exposure coupled with disproportionate co-localization of PFAS-polluting facilities in under-resourced communities may exacerbate disparities in PFAS-associated health risks.

methodWe leveraged two cohorts in Southern California with 8 PFAS concentrations measured in plasma. We obtained PFAS water testing data from the Third Unregulated Contaminant Monitoring Rule and state monitoring data, census tract-level information on food access using the Food Access Research Atlas, the location of Superfund sites on the National Priorities List, and data on facilities known to release PFAS pollutants. These data were then spatially linked to the participants' home addresses.

resultsIn the first cohort, we found that detections of PFOS, PFOA, and PFHxS in drinking water were associated with 1.54 ng/mL (95% CI: 0.77, 2.32), 0.47 ng/mL (0.25, 0.68), and 1.16 ng/mL (0.62, 1.71) increase in plasma PFOS, PFOA, and PFHxS. The presence of Superfund sites was associated with higher plasma concentrations of PFOS, PFHxS, PFPeS, and PFHpS (betas [95% CIs]: 0.96 [0.21, 1.71], 0.9 [0.22, 1.58], 0.04 [0.02, 0.06] and 0.05 [0.02, 0.09], respectively). Each additional PFAS-polluting facility present in the neighborhood was associated with a 0.9 ng/mL (0.03, 0.15) increase in the concentration of PFOS. In the other cohort, we found that the presence of Superfund sites was associated with higher plasma PFDA, PFHpS, PFOS (betas [95% CIs]: 0.03 [0.01, 0.06], 0.05 [0.01, 0.09], and 1.96 [0.31, 3.62]). Neighborhood low access to food was associated with a 2.51 ng/mL (0.7, 4.31) increase in plasma PFOS, 0.6 ng/mL (0.16, 1.06) increase in plasma PFOA and 0.06 (0.02, 0.1) increase in plasma PFHpS.

conclusionReducing sources of PFAS exposure in under-resourced neighborhoods may help reduce disparities in human exposure levels.

Indexed as

Drinking WaterFluorocarbonsWater Pollutants, ChemicalAdultAgedCaliforniaCohort StudiesEnvironmental ExposureEnvironmental MonitoringFemaleHumansMaleMiddle AgedYoung AdultDrinking WaterFluorocarbonsWater Pollutants, ChemicalDrinking waterFood accessIndustryPFASSuperfund site

Identifiers

PMID39549910
PMCPMC11631652

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