Evidence map›Paper›PMID 39549701›Full record

ArticleCurrent biology : CB2024

Rapid sensorimotor adaptation to auditory midbrain silencing in free-flying bats.

Clarice A Diebold, Jennifer Lawlor, Kathryne Allen, Grace Capshaw, Megan G Humphrey, Diego Cintron-De Leon, Kishore V Kuchibhotla, Cynthia F Moss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Neuronal activity underlying vocal production in bats.Annals of the New York Academy of Sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clarice A DieboldDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: clarice.diebold@gmail.com.
Jennifer LawlorDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: jlawlor3@jhu.edu.
Kathryne AllenDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Grace CapshawDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Megan G HumphreyDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Diego Cintron-De LeonDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Kishore V KuchibhotlaDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Cynthia F MossDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Funding

Training Program in Hearing and BalanceT32DC000023 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CULLEN, KATHLEEN E · 1989 to 2025
$8.7M
Auditory-based navigation: attentional shifts rapidly modulate hippocampal codesR01NS121413 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MOSS, CYNTHIA F, ULANOVSKY, NACHUM · 2021 to 2025
$2.2M
Optical tools to probe neural circuits in the echolocating batR34NS118462 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KUCHIBHOTLA, KISHORE V, WOHLGEMUTH, MELVILLE J · 2020 to 2020
$705k
NIDCD NIH HHS T32 DC000023NINDS NIH HHS R01 NS121413NINDS NIH HHS R34 NS118462
6 · The paper itself

Abstract

Echolocating bats rely on rapid processing of auditory information to guide moment-to-moment decisions related to echolocation call design and flight path selection. The fidelity of sonar echoes, however, can be disrupted in natural settings due to occlusions, noise, and conspecific jamming signals. Behavioral sensorimotor adaptation to external blocks of relevant cues has been studied extensively, but little is known about adaptations that mitigate internal sensory flow interruption. How do bats modify their sensory-guided behaviors in natural tasks when central auditory processing is interrupted? Here, we induced internal sensory interruptions by reversibly inactivating excitatory neurons in the inferior colliculus (IC) using ligand-activated inhibitory designer receptors exclusively activated by designer drugs (DREADDs). Bats were trained to navigate through one of three open windows in a curtain to obtain a food reward, while their echolocation and flight behaviors were quantified with synchronized ultrasound microphone and stereo video recordings. Under control conditions, bats reliably steered through the open window, only occasionally contacting the curtain edge. Suppressing IC excitatory activity elevated hearing thresholds, disrupted overall performance in the task, increased the frequency of curtain contact, and led to striking compensatory sensorimotor adjustments. DREADDs-treated bats modified flight trajectories to maximize returning echo information and adjusted sonar call design to boost detection of obstacles. Sensorimotor adaptations appeared immediately and did not change over successive trials, suggesting that these behavioral adaptations are mediated through existing neural circuitry. Our findings highlight the remarkable rapid adaptive strategies bats employ to compensate for internal sensory interruptions to effectively navigate their environments.

Indexed as

Adaptation, PhysiologicalChiropteraEcholocationFlight, AnimalInferior ColliculiAnimalsAuditory PerceptionFemaleMaleDREADDsEcholocationhearinginferior colliculusnavigation

Identifiers

PMID39549701
PMCPMC11614681

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.