ArticleCell2025
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice.
Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Longitudinal changes in endocannabinoids and clinical course of adolescent non-suicidal self-injury.Translational psychiatry · 2026Article
- Generalization of negative memories drives the development of psychological distress-related behaviors.Innovation (Cambridge (Mass.)) · 2026Article
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- The Amygdala and Politics.Brain sciences · 2026Review
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Hcn1-dependent engram neurons in the PVN encode gastric inflammatory sensitization.Science advances · 2026Article
- Article
- Chronic stress enhances threat responding and impacts fear extinction.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Identification of somatostatinProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A network analysis of post-traumatic stress disorder, anxiety, and depression in women with pregnancy loss.Reproductive health · 2026Article
- Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adrenarche as a regulator of sensitivity to early adversity.Journal of neuroendocrinology · 2026Review
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Multi-scale imaging and recording of in-vivo neural activity.BMB reports · 2026Review
- Relationships among peri-traumatic circulating endocannabinoids and long-term, negative outcomes following traumatic injury.Psychopharmacology · 2026Article
- Memory engram synapse 3D macromolecular architecture visualized by cryoCLEM-guided cryoET.Structure (London, England : 1993) · 2026Article
- Network analysis of anxiety, depression, stress, and sleep disturbances in healthcare workers.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons active during an event (an engram ensemble). We examined the molecular and circuit processes mediating stress-induced threat memory overgeneralization in mice. Stress, acting via corticosterone, increased the density of engram ensembles supporting a threat memory in lateral amygdala, and this engram ensemble was reactivated by both specific and non-specific retrieval cues (generalized threat memory). Furthermore, we identified a critical role for endocannabinoids, acting retrogradely on parvalbumin-positive (PV+) lateral amygdala interneurons in the formation of a less-sparse engram and memory generalization induced by stress. Glucocorticoid receptor antagonists, endocannabinoid synthesis inhibitors, increasing PV+ neuronal activity, and knocking down cannabinoid receptors in lateral amygdala PV+ neurons restored threat memory specificity and a sparse engram in stressed mice. These findings offer insights into stress-induced memory alterations, providing potential therapeutic avenues for stress-related disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.