Evidence map›Paper›PMID 39549607›Full record

ReviewCurrent opinion in genetics & development2024

How our brains are built: emerging approaches to understand human-specific features.

Nicole D Moss, Davoneshia Lollis, Debra L Silver

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole D MossDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Davoneshia LollisDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: https://twitter.com/@_mlollis.
Debra L SilverDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Cell Biology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences and Duke Regeneration Center, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: debra.silver@duke.edu.

Funding

Mechanisms of neural progenitor division in the developing brainR01NS083897 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2013 to 2023
$3.4M
Investigating sex differences in DDX3X mouse modelsR01NS120667 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA L. · 2021 to 2025
$3.4M
Roles for uniquely human enhancers in brain development and WNT signalingR01MH132089 · NIMH · DUKE UNIVERSITY · PI Debra L. Silver · 2023 to 2026
$2.6M
Distal mRNA localization and translation in neural stem cells of the developing brainR37NS110388 · NINDS · DUKE UNIVERSITY · PI Debra L. Silver · 2024 to 2026
$2.2M
Human-specific splicing regulation in neurogenesis and diseaseF32NS138224 · NINDS · DUKE UNIVERSITY · PI MOSS, NICOLE D · 2025 to 2025
$48k
NIMH NIH HHS R01 MH132089NINDS NIH HHS F32 NS138224NINDS NIH HHS R01 NS083897NINDS NIH HHS R01 NS120667NINDS NIH HHS R37 NS110388
6 · The paper itself

Abstract

Understanding what makes us uniquely human is a long-standing question permeating fields from genomics, neuroscience, and developmental biology to medicine. The discovery of human-specific genomic sequences has enabled a new understanding of the molecular features of human brain evolution. Advances in sequencing, computational, and in vitro screening approaches collectively reveal new roles of uniquely human sequences in regulating gene expression. Here, we review the landscape of human-specific loci and describe how emerging technologies are being used to understand their molecular functions and impact on brain development. We describe current challenges in the field and the potential of integrating new hypotheses and approaches to propel our understanding of the human brain.

Indexed as

BrainGenomicsGenome, HumanHumans

Identifiers

PMID39549607
PMCPMC13333196

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.