Evidence map›Paper›PMID 39549468›Full record

ReviewVision research2025

Exfoliation syndrome genetics in the era of post-GWAS.

Ola A Elsayed, Jingwen Cai, Yutao Liu

Abstract readReview
In one paragraph

Review in Vision research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ola A ElsayedDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
Jingwen CaiDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
Yutao LiuDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA; Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: yutliu@augusta.edu.

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Gene Discovery in Familial KeratoconusR01EY023242 · NEI · DUKE UNIVERSITY · PI LIU, YUTAO · 2013 to 2023
$3.4M
Estrogen and its Receptor in Intraocular Pressure RegulationR01EY032960 · NEI · MAYO CLINIC ROCHESTER · PI Yutao Liu · 2023 to 2026
$1.6M
Long Noncoding RNA lncLOXL1 and Exfoliation Syndrome.R21EY028671 · NEI · AUGUSTA UNIVERSITY · PI LIU, YUTAO · 2018 to 2019
$467k
MIR182 and Ocular Hypertension.R21EY033961 · NEI · AUGUSTA UNIVERSITY · PI LIU, YUTAO · 2023 to 2024
$424k
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY023242NEI NIH HHS R01 EY032960NEI NIH HHS R21 EY028671NEI NIH HHS R21 EY033961
6 · The paper itself

Abstract

Exfoliation syndrome (XFS), or pseudoexfoliation syndrome, is considered a systemic disorder that leads to glaucoma with progressive visual field loss. A better insight into the underlying pathogenic mechanism will help diagnose the disease and prevent and slow progression. Here, we provide an overview of disease pathogenesis in the light of GWAS and multi-omics research. We discuss possible environmental interactions related to XFS. We investigate the potential interactions in differentially expressed genes from RNA-Seq by using Ingenuity Pathway Analysis. MAPK pathway was identified as the top network of these genes. Further investigation is needed to verify our results in vivo. It is necessary to establish an animal model mimicking exfoliation syndrome phenotypes.

Indexed as

Exfoliation SyndromeGenome-Wide Association StudyAnimalsHumansExfoliation glaucomaExfoliation syndromeGeneticsLOXL1Post-GWAS

Identifiers

PMID39549468
PMCPMC11624108

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.