ArticleDrug and alcohol dependence2024
An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients.
Article in Drug and alcohol dependence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Organisational practices in postoperative opioid prescribing at discharge in UK NHS day surgery units: the OPIOID-discharge survey.Anaesthesia · 2026Article
- Reducing Prescription Opioid Dose and Duration to Reduce Risk of Opioid Use Disorder Among Patients With Musculoskeletal Pain.Epidemiology (Cambridge, Mass.) · 2025Article
- A national cohort study of long-term opioid prescription and sociodemographic and health care-related risk factors.Communications medicine · 2025Article
- Article
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3 authors.
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Abstract
objectivesThis retrospective cohort study provides an updated view on the association between the likelihood of long-term opioid use (LTOU) and characteristics of the initial opioid prescription (dose, opioid type) and initial opioid prescription episode (days' supplied) among opioid-naïve patients utilizing IQVIA PharMetrics®Plus for Academics database representative of commercially insured patients in the US.
methodsKaplan-Meier estimates were used to determine opioid continuation likelihood at 365 days stratified by the characteristics of the initial opioid prescription and initial opioid prescription episode. Cox-proportional hazard models were estimated to determine the strength of association between initial opioid prescription characteristics and opioid continuation.
resultsA total of 578,403 cancer-free, SUD-free, opioid-naïve subjects aged ≥14 years that filled ≥1 opioid prescriptions between April 13, 2016 and April 18, 2020 were identified and categorized based on time to opioid discontinuation. After accounting for censoring, 5.05 % of persons continued opioid use for ≥365 days. Compared to a 1-2 days' supply (DS), the likelihood of opioid discontinuation was consistently lower with higher DS [HRs (CIs): 3-4 days' supply = 0.66 (0.65-0.66); 5-7 DS = 0.41 (0.41-0.41); 8-10 DS = 0.33 (0.33-0.34); 11-14 DS = 0.30 (0.29-0.31); 15-21 DS = 0.26 (0.26-0.27); ≥22 DS = 0.17 (0.17-0.18)]. These associations between increased DS and decreased likelihood of discontinuing opioid remained consistent across different pain etiologies.
conclusionsIn this era of more conservative opioid prescribing, increases in DS remains the strongest factor associated with a higher likelihood of LTOU.
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