Evidence map›Paper›PMID 39549212›Full record

ArticleJournal of endocrinological investigation2025

Urinary titin as a biomarker of sarcopenia in diabetes: a propensity score matching analysis.

Y Takiguchi, R Tsutsumi, M Shimabukuro, H Tanabe, A Kawakami, M Hyodo, K Shiroma, H Saito, M Matsuo, H Sakaue

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
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  5. Review
  6. Review
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  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Y TakiguchiDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, 960-1295, Fukushima, Japan.
R TsutsumiDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.
M ShimabukuroDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, 960-1295, Fukushima, Japan. mshimabukuro-ur@umin.ac.jp.ORCID http://orcid.org/0000-0001-7835-7665
H TanabeDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, 960-1295, Fukushima, Japan.
A KawakamiDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.
M HyodoDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.
K ShiromaDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, 960-1295, Fukushima, Japan.
H SaitoDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, 960-1295, Fukushima, Japan.
M MatsuoResearch Center for Locomotion Biology and KNC Department of Nucleic Acid Drug Discovery, Faculty of Rehabilitation, Kobe Gakuin University, Kobe, Japan.
H SakaueDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Funding

Japan Agency for Medical Research and Development 965304Japanese Foundation for Research and Promotion of Endoscopy 21K11724Japanese Foundation for Research and Promotion of Endoscopy 22H03535Japanese Foundation for Research and Promotion of Endoscopy JP16K01823 and 22K11729
6 · The paper itself

Abstract

purposeMeasuring urinary titin levels is expected to be useful in screening for muscle damage or injury in various diseases. We evaluated whether urinary titin levels were elevated in individuals with type 2 diabetes mellitus (T2DM) and how urinary titin levels were associated with the diagnosis of sarcopenia in T2DM.

methodsWe performed a cross-sectional analysis of 114 controls and 515 patients with T2DM. Multivariate-adjusted models were used to determine the odds ratios (OR) of urinary titin cutoff values for diagnosing sarcopenia.

resultsUrinary titin levels were higher in the T2DM group than in the non-diabetes group after propensity score matching (median [IQR] 3.2 [2.3, 4.6] vs. 4.4 [2.7, 6.9] pmol/mg·creatinine). T2DM was associated with high titin levels after correction for comorbidities (odds ratio 2.46, 95% confidence interval (CI) 1.29-4.70, P = 0.006) but not after correction for sarcopenia-associated factors. Urinary titin levels above the cutoff value showed an odd ratio of 6.61 (age- and body mass index-adjusted, 1.26-34.6, P = 0.021) for the diagnosis of sarcopenia in men with T2DM aged ≥ 75 years.

conclusionResults indicated that T2DM was associated with a high-titin state and that the urinary titin cutoff value could be useful for identifying candidates at high risk for sarcopenia, such as elderly men.

Indexed as

ConnectinDiabetes Mellitus, Type 2SarcopeniaAgedBiomarkersCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrognosisPropensity ScoreBiomarkersConnectinTTN protein, humanBiomarkersSarcopeniaScreeningSkeletal MuscleType 2 Diabetes

Identifiers

PMID39549212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.