Evidence map›Paper›PMID 39549135›Full record

ArticleJournal of medical ultrasonics (2001)2025

Acoustic radiation force impulse (push pulse)-induced lung hemorrhage: investigating the effect of ultrasound contrast agent in rabbits.

Noriya Takayama, Hideki Sasanuma, Kazuma Rifu, Naotaka Nitta, Iwaki Akiyama, Nobuyuki Taniguchi

Abstract read
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In one paragraph

Article in Journal of medical ultrasonics (2001), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Noriya TakayamaDepartment of Clinical Laboratory Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. noriya.takkan@gmail.com.ORCID http://orcid.org/0000-0002-7489-6159
Hideki SasanumaDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Kazuma RifuDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Naotaka NittaHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
Iwaki AkiyamaMedical Ultrasound Research Center, Doshisha University, Kyotanabe, Kyoto, Japan.
Nobuyuki TaniguchiDepartment of Clinical Laboratory Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Funding

Japan Society for the Promotion of Science 16K01418Japan Society for the Promotion of Science 19K12847Japan Society for the Promotion of Science 23K11901
6 · The paper itself

Abstract

purposeAcoustic radiation force impulse (ARFI) elastography and contrast-enhanced ultrasonography (CEUS) are emerging techniques that are becoming common in ultrasound examinations. We previously reported that ARFI (push pulse) induced lung hemorrhage in rabbits, indicating that greater risks are associated with ARFI than with conventional ultrasound. In this study, we assessed the risk of lung hemorrhage under a combination of ARFI elastography and CEUS, considering potential exacerbation of ARFI-induced lung hemorrhage as a result of the ultrasound contrast agent (UCA) used in CEUS.

methodsTwenty-three rabbits were divided into non-UCA and UCA groups. ARFI exposure parameters were set at six mechanical index (MI) levels (0.29, 0.45, 0.60, 0.88, 1.0, 1.39) in non-UCA groups and five MI levels (0.29, 0.66, 0.88, 0.97, 1.25) in UCA groups. Lung exposure was performed bilaterally through the intercostal space in each rabbit. Lung damage was assessed through macroscopic and microscopic observation post euthanasia.

resultsLung hemorrhage was detected at MI

conclusionThis study demonstrates that UCA does not significantly worsen ARFI-induced lung hemorrhage in terms of occurrence or severity. However, risks and benefits of ARFI elastography on the lung should be considered, irrespective of UCA administration.

Indexed as

Contrast MediaElasticity Imaging TechniquesHemorrhageLung DiseasesAnimalsDisease Models, AnimalLungMaleRabbitsContrast MediaAcoustic radiation force impulseHemorrhageLungMechanical indexUltrasound contrast agent

Identifiers

PMID39549135
PMCPMC13056766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.