Evidence map›Paper›PMID 39549065›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Biofabricated zinc oxide nanoparticles mitigate acrylamide-induced immune toxicity and modulate immune-related genes and microRNA in rats.

Ayman A Saleh, Ahmed Abdulwahab Bawahab, Duaa Abdullah Bafail, Manal E Alosaimi, Yasmina M Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Mohamed M M Metwally, Badriyah S Alotaibi, Mohamed El-Gamal and 3 more

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Ayman A SalehDepartment of Pathology, College of Medicine, University of Hail, Hail, Saudi Arabia.
Ahmed Abdulwahab BawahabDepartment of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Duaa Abdullah BafailDepartment of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Manal E AlosaimiDepartment of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O Box 84428, 11671, Riyadh, Saudi Arabia. Mealosaimi@pnu.edu.sa.
Yasmina M Abd-ElhakimDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Amany Abdel-Rahman MohamedDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Tarek KhamisDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Mohamed M M MetwallyDepartment of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, King Salman International University, Ras Sidr, Egypt.
Badriyah S AlotaibiDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Mohamed El-GamalForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Naief DahranDepartment of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Ahlam Saleh AlamriDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al-Quwayiyah, Shaqra University, Riyadh, Saudi Arabia.
Naira ElAshmounyHistology and Cell Biology, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the potential efficacy of eco-friendly biofabricated zinc oxide nanoparticles (GS-ZnONP) (10 mg/kg b.wt) to reduce the impacts of long-term oral acrylamide (ALD) exposure (20 mg/kg b.wt) on the blood cells, immune components, splenic oxidative status, and expression of CD20, CD3, CD4, CD8, TNF-α, caspase-3, microRNA-181a-5p, and microRNA-125-5p in rats in a 60-day experiment. The study findings revealed that GS-ZnONP significantly corrected the ALD-induced hematological alterations. Additionally, the ALD-induced increase in the serum C3, splenic ROS, CD4, CD8, and MDA and histological alterations were significantly repressed in the ALD + GS-ZnONP-treated rats. Instead, the depleted splenic antioxidants and Zn contents were markedly reestablished in the ALD + GS-ZnONP-treated group. Additionally, a significant upregulation of expression of splenic CD3, CD4, CD8, CD20, TNF-α, and caspase-3, but downregulation of microRNA-181a-5p and microRNA-125-5p was detected in the ALD-exposed group. Yet, the former deviations in the gene expressions were corrected in the ALD + GS-ZnONP-treated rats. Furthermore, GS-ZnONP treatment significantly minimized the increased caspase-3 and TNF-α immunoexpression in the splenic tissues of ALD-exposed rats. Conclusively, the study findings proved the efficacy of GS-ZnONP in rescuing ALD-induced disturbances in blood cell populations, immune function, splenic antioxidant status, and immune-related gene expression.

Indexed as

AcrylamideMetal NanoparticlesMicroRNAsNanoparticlesZinc OxideAnimalsAntioxidantsMaleOxidative StressRatsRats, WistarSpleenAcrylamideAntioxidantsMicroRNAsZinc OxideAcrylamideAnemiaCD3ImmunohistochemistryMicroRNA-125-5pZinc oxide nanoparticles

Identifiers

PMID39549065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.