ArticleAnalytical and bioanalytical chemistry2025
Enhanced industrial wastewater monitoring: method development for non-target screening of highly polar substances using ZIC-HILIC-HRMS.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- ZICcHILIC-HRMS as a complementary approach to IC-HRMS for highly polar contaminants in water: a method-specific assessment.Analytical and bioanalytical chemistry · 2026Article
- Comparative non-target screening of advanced oxidation process (AOP)-integrated industrial wastewater treatment using RP and mixed-mode chromatography.Analytical and bioanalytical chemistry · 2026Article
- Persistent and Mobile Organic Contaminants: Quantification and Nontarget Analysis in Greater Boston Drinking and Surface Water.ACS environmental Au · 2026Article
- Quantifying protein residues in APIs: Bradford assay mechanism and limitations, outperformed by HILIC-MS/MS.Journal of pharmaceutical analysis · 2026Article
- Ion chromatography high-resolution mass spectrometry-quality assurance by co-injection of internal standards.Analytical and bioanalytical chemistry · 2026Article
- Exploring non-target screening variability in unsupervised multivariate time trend analysis of LC-HRMS data.Analytical and bioanalytical chemistry · 2026Article
- Screening and optimization of online comprehensive two-dimensional liquid chromatography conditions for the analysis of hospital wastewater.Analytical and bioanalytical chemistry · 2026Article
- Not One Method to Rule Them All: A Comparative Study of Chromatographic Platforms (RP-LC-, HILIC-, SFC-, and IC-HRMS) for Water Analysis.Analytical chemistry · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Non-target screening (NTS) plays a major role in the monitoring and management of water bodies. While the NTS of moderate to non-polar substances is well-established, the screening of highly polar chemicals remains challenging. In this study, a robust separation method for highly polar substances using zwitterionic hydrophilic interaction liquid chromatography coupled with high-resolution mass spectrometry (ZIC-HILIC-HRMS) was developed. This method was specifically designed for the NTS of industrial wastewater, with the objective of capturing a wide range of polar contaminants in each acquisition run. Method validation included assessing key parameters such as repeatability, reproducibility, linearity, and limit of detection (LOD). For repeatability and reproducibility, the average %RSD of intensity and retention time across all substances in different matrices-solvent, influent, and effluent-remained below 6% and 1%, respectively (n = 10). The method demonstrated good linearity (R
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