Evidence map›Paper›PMID 39548981›Full record

ArticleJournal of neurophysiology2024

Hypercapnia impacts neural drive and timing of diaphragm neuromotor control.

Obaid U Khurram, Maximilian J Kantor-Gerber, Carlos B Mantilla, Gary C Sieck

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025
    Review
  5. A cholinergic spinal pathway for the adaptive control of breathing.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Obaid U KhurramDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-9103-4713
Maximilian J Kantor-GerberDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
Carlos B MantillaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-5446-9208
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-3040-9424

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Enhancing Respiratory Motor Function after Spinal Cord InjuryR01HL146114 · NHLBI · MAYO CLINIC ROCHESTER · PI Carlos B Mantilla, Gary C. Sieck · 2019 to 2026
$5.4M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL146114NHLBI NIH HHS R01 HL146114NIA NIH HHS R01 AG044615
6 · The paper itself

Abstract

The neuromotor control of the diaphragm muscle (DIAm) involves motor unit recruitment, sustained activity (incrementing and decrementing), and motor unit derecruitment, phases that may be modified to maintain ventilation across conditions. The primary goal of the present study was to investigate the effects of hypercapnia, which increases respiratory rate and tidal volume, on DIAm neuromotor control in awake rats. We recorded DIAm electromyography (EMG) with implanted chronic fine-wire electrodes in nine Sprague-Dawley rats during normocapnia and hypercapnia (7% CO

Indexed as

DiaphragmHypercapniaRats, Sprague-DawleyRecruitment, NeurophysiologicalAnimalsElectromyographyMaleMotor NeuronsRatsdiaphragmEMGhypercapniamotor controlstationarity

Identifiers

PMID39548981
PMCPMC11687830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.