Evidence map›Paper›PMID 39548965›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Genetic reduction of skeletal muscle glycogen synthase 1 abundance reveals that the refeeding-induced reversal of elevated insulin-stimulated glucose uptake after exercise is not attributable to achieving a high muscle glycogen concentration.

Seong Eun Kwak, Haiyan Wang, Xiufang Pan, Dongsheng Duan, Gregory D Cartee

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seong Eun KwakMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-3666-2618
Haiyan WangMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-0237-4319
Xiufang PanDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0002-2594-5911
Dongsheng DuanDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0003-4109-1132
Gregory D CarteeMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-5311-1722

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Skeletal Muscle Glucose Uptake: Exercise and InsulinR01DK071771 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARTEE, GREGORY D. · 2006 to 2020
$4.5M
Regulation of Elevated Postexercise Insulin-stimulated Glucose Uptake by Skeletal MuscleR01DK136700 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory D. Cartee · 2024 to 2026
$1.8M
HHS | National Institutes of Health (NIH) R01-DK-071771HHS | National Institutes of Health (NIH) R01-DK-136700NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK071771NIDDK NIH HHS R01 DK136700
6 · The paper itself

Abstract

One exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle. Postexercise refeeding induces reversal of postexercise (PEX)-enhanced ISGU concomitant with attaining high muscle glycogen in rats. To test the relationship between high glycogen and reversal of PEX-ISGU, we injected one epitrochlearis muscle from each rat with adeno-associated virus (AAV) small hairpin RNA (shRNA) that targets glycogen synthase 1 (GS1) and injected contralateral muscles with AAV-shRNA-Scrambled (Scr). Muscles from PEX and sedentary rats were collected at 3-hour PEX (3hPEX) or 6-hour PEX (6hPEX). Rats were either not refed or refed rat-chow during the recovery period. Isolated muscles were incubated with [

Indexed as

GlucoseGlycogenGlycogen SynthaseInsulinMuscle, SkeletalPhysical Conditioning, AnimalAnimalsMaleRatsRats, Sprague-DawleyRNA, Small InterferingGlucoseGlycogenGlycogen SynthaseInsulinRNA, Small Interfering

Identifiers

PMID39548965
PMCPMC11698010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.