Evidence map›Paper›PMID 39548812›Full record

ArticleProtein science : a publication of the Protein Society2024

The transmission of mutation effects in a multiprotein machine: A comprehensive metadynamics study of the cardiac thin filament.

Krishna Prasad Ghanta, Romi L Castillo, Jil C Tardiff, Steven D Schwartz

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Krishna Prasad GhantaDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona, USA.
Romi L CastilloDepartment of Biomedical Engineering, The University of Arizona, Tucson, Arizona, USA.
Jil C TardiffDepartment of Biomedical Engineering, The University of Arizona, Tucson, Arizona, USA.
Steven D SchwartzDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-0308-1059

Funding

The interaction of myosin and the thin filament: how mutations cause allosteric dysfunction and their connection to genetic cardiomyopathyR01HL107046 · NHLBI · UNIVERSITY OF ARIZONA · PI SCHWARTZ, STEVEN D, TARDIFF, JIL C · 2011 to 2023
$6.0M
NHLBI NIH HHS R01 HL107046NIH HHS HL107046
6 · The paper itself

Abstract

The binding of Ca

Indexed as

Troponin TCalciumHumansMolecular Dynamics SimulationMutationPoint MutationProtein ConformationTropomyosinCalciumTropomyosinTroponin Tallosterycardiac thin filamenthypertrophic cardiomyopathymutation

Identifiers

PMID39548812
PMCPMC11568392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.