Evidence map›Paper›PMID 39548810›Full record

ArticleFoot & ankle international2025

Subchondral Bone Degeneration and Pathology 3-15 Years Following Ankle Sprain Injury in Adolescent Sport.

Kirsten N Bott, Michael T Kuczynski, Oluwatoyosi B A Owoeye, Jacob L Jaremko, Koren E Roach, Jean-Michel Galarneau, Carolyn A Emery, Sarah L Manske

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foot & ankle international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kirsten N BottDepartment of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-5140-5372
Michael T KuczynskiMcCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Oluwatoyosi B A OwoeyeDepartment of Physical Therapy and Athletic Training, Doisy College of Health Sciences, Saint Louis University, Saint Louis, MO, USA.ORCID 0000-0002-5984-9821
Jacob L JaremkoDepartment of Radiology and Diagnostic Imaging, University of Alberta, Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada.
Koren E RoachDepartment of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jean-Michel GalarneauSports Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
Carolyn A EmeryMcCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sarah L ManskeDepartment of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSport-related ankle sprains (SASs) are prevalent in adolescents (ages 10-19), increasing the risk of developing posttraumatic osteoarthritis (PTOA). Although early ankle osteoarthritis (OA) is not well defined, OA eventually includes alterations in bone mineral density (BMD), structural changes, and soft tissue pathology. This study examined the impact of SAS sustained in adolescent sport on bone and soft tissue structural outcomes 3-15 years postinjury.

methodsParticipants (n = 10) with prior unilateral SAS in adolescent sport (HxAI) were compared to age- and sex-matched controls. To assess injury-related pathologies and BMD, 1.5-tesla (T) extremity magnetic resonance imaging (MRI) and computed tomography scans were used. Semiquantitative scores for injury patterns and OA features from MRI scans were summed and compared between groups. The talus, calcaneus, navicular, and 5% distal tibia were segmented, and BMD was measured for each bone.

resultsAll HxAI participants exhibited MRI injury pathology (median 2; IQR 1-6), whereas only 1 of 10 controls showed pathology (median 0; IQR 0-0), χ

conclusionThe presence of injury pattern pathology, structural changes, and reduced talus BMD suggest that degenerative changes may occur in individuals as early as 3-15 years following ankle injury.

Indexed as

Ankle InjuriesAthletic InjuriesOsteoarthritisSprains and StrainsAdolescentAdultBone DensityChildCross-Sectional StudiesFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleTarsal BonesTibiaadolescent sportankle spraincomputed tomographymagnetic resonance imagingposttraumatic osteoarthritis

Identifiers

PMID39548810
PMCPMC11697491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.