Evidence map›Paper›PMID 39548749›Full record

ArticleOncoimmunology2024

Estrogen-related differences in antitumor immunity and gut microbiome contribute to sexual dimorphism of colorectal cancer.

Georgia Lattanzi, Federica Perillo, Angélica Díaz-Basabe, Bruna Caridi, Chiara Amoroso, Alberto Baeri, Elisa Cirrincione, Michele Ghidini, Barbara Galassi, Elisa Cassinotti and 6 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Sex-based molecular and prognostic disparities in pan-cancer: an analysis across the global cohorts.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. The gut microbiota in cancer immunity and immunotherapy.Cellular & molecular immunology · 2025
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Georgia LattanziGastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Federica PerilloDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Angélica Díaz-BasabeDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Bruna CaridiGastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Chiara AmorosoGastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Alberto BaeriDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Elisa CirrincioneDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Michele GhidiniMedical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Barbara GalassiMedical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Elisa CassinottiDepartment of General & Minimally Invasive Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Ludovica BaldariDepartment of General & Minimally Invasive Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Luigi BoniDepartment of General & Minimally Invasive Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Maurizio VecchiGastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Flavio CaprioliGastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Federica FacciottiDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Francesco StratiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.ORCID 0000-0001-7217-3355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a multifaceted disease whose development and progression varies depending on tumor location, age of patients, infiltration of immune cells within cancer lesions, and the tumor microenvironment. These pathophysiological characteristics are additionally influenced by sex-related differences. The gut microbiome plays a role in initiation and progression of CRC, and shapes anti-tumor immune responses but how responsiveness of the immune system to the intestinal microbiota may contribute to sexual dimorphism of CRC is largely unknown. We studied survival, tumor-infiltrating immune cell populations and tumor-associated microbiome of a cohort of

Indexed as

Colorectal NeoplasmsEstrogensGastrointestinal MicrobiomeSex CharacteristicsAdultAgedFemaleHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedNatural Killer T-CellsTumor MicroenvironmentEstrogensColorectal cancergender medicinegut microbiomeiNKTsexual dimorphismtumor immunology

Identifiers

PMID39548749
PMCPMC11572150

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.