Evidence map›Paper›PMID 39548533›Full record

ArticleBreast cancer research : BCR2024

Exposure to air pollutants and breast cancer risk: mediating effects of metabolic health biomarkers in a nested case-control study within the E3N-Generations cohort.

Benoît Mercoeur, Béatrice Fervers, Thomas Coudon, Hwayoung Noh, Camille Giampiccolo, Lény Grassot, Elodie Faure, Florian Couvidat, Gianluca Severi, Francesca Romana Mancini and 3 more

Abstract read
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In one paragraph

Article in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Benoît MercoeurDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Béatrice FerversDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Thomas CoudonDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Hwayoung NohDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Camille GiampiccoloDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Lény GrassotDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Elodie FaureUniversite Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 94805, Villejuif, France.
Florian CouvidatNational Institute for Industrial Environment and Risks (INERIS), Verneuil-en-Halatte, France.
Gianluca SeveriUniversite Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 94805, Villejuif, France.
Francesca Romana ManciniUniversite Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 94805, Villejuif, France.
Pascal RoyLaboratoire de Biométrie Et Biologie Evolutive, CNRS UMR 5558, Villeurbanne, France.
Delphine PraudDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France.
Amina AmadouDepartment of Prevention Cancer Environnement, Centre Léon Bérard, Lyon, France. amina.amadou@lyon.unicancer.fr.

Funding

Agence de la transition écologique 21ESD0020Agence Nationale de la Recherche ANR-10-COHO-0006Ligue Contre le Cancer 18-383-CMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovation 2102 918823
6 · The paper itself

Abstract

backgroundGrowing epidemiological evidence suggests an association between exposure to air pollutants and breast cancer. Yet, the underlying mechanisms remain poorly understood. This study explored the mediating role of thirteen metabolic health biomarkers in the relationship between exposure to three air pollutants, i.e. nitrogen dioxide (NO

methodsWe used data from a nested case-control study within the French national prospective E3N-Generations cohort, involving 523 breast cancer cases and 523 matched controls. The four-way decomposition mediation of total effects for thirteen biomarkers was applied to estimate interaction and mediation effects (controlled direct, reference interaction, mediated interaction, and pure indirect effects).

resultsThe analyses indicated a significant increase in breast cancer risk associated with BaP exposure (odds ratio (OR)

conclusionAlthough limited by a lack of statistical power, this study provides relevant insights into the potential mediating role of certain biomarkers in the association between air pollutant exposure and breast cancer risk, highlighting the need for further in-depth studies in large populations.

Indexed as

Air PollutantsBreast NeoplasmsEnvironmental ExposurePolychlorinated BiphenylsAdultAgedBenzo(a)pyreneBiomarkersBiomarkers, TumorCase-Control StudiesFemaleFranceHumansMiddle AgedNitrogen DioxideOdds Ratio2,4,5,2',4',5'-hexachlorobiphenylAir PollutantsBenzo(a)pyreneBiomarkersBiomarkers, TumorNitrogen DioxidePolychlorinated BiphenylsAir pollutantsBiomarkersBreast cancerInteractionMediation

Identifiers

PMID39548533
PMCPMC11568591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.