Evidence map›Paper›PMID 39548226›Full record

ArticleScientific reports2024

Identifying amyotrophic lateral sclerosis using diffusion tensor imaging, and correlation with neurofilament markers.

Jiangbo Qin, Xiaochun Wang, Guiling Fan, Wei Zhang, Xiaofeng Wu, Bin Wang, Yanming Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiangbo QinDepartment of Radiology, First Hospital of Shanxi Medical University, No. 85, Jiefang South Street, Taiyuan, Shanxi, China.
Xiaochun WangDepartment of Radiology, First Hospital of Shanxi Medical University, No. 85, Jiefang South Street, Taiyuan, Shanxi, China.
Guiling FanDepartment of Pathology, Chinese Medical Hospital of Shanxi, No. 16, Bingzhou West Street, Taiyuan, Shanxi, China.
Wei ZhangDepartment of Neurology, First Hospital of Shanxi Medical University, No. 85, Jiefang South Street, Taiyuan, Shanxi, China.
Xiaofeng WuDepartment of Radiology, First Hospital of Shanxi Medical University, No. 85, Jiefang South Street, Taiyuan, Shanxi, China.
Bin WangDepartment of Radiology, First Hospital of Shanxi Medical University, No. 85, Jiefang South Street, Taiyuan, Shanxi, China.
Yanming LiuFirst Department of Geriatric Diseases, First Hospital of Shanxi Medical University, No. 85, Jiefang South Street, Taiyuan, Shanxi, China. liuyanming215@163.com.

Funding

the Basic Research Project of Shanxi Province 202103021224405the Key Research and Development Project Plan of Shanxi Province concerning social advancement 201903D321049
6 · The paper itself

Abstract

To determine diagnostic value of diffusion tensor imaging (DTI) in amyotrophic lateral sclerosis (ALS) patients and investigate the association between DTI and neurofilaments (NFs), including serum and cerebrospinal fluid (CSF) levels of neurofilament light chain (NFL) and phosphorylated neurofilament heavy chain (pNFH). Forty-three clinically diagnosed ALS patients and 32 control subjects without neurological disorders underwent routine MRI (magnetic resonance imaging) and DTI scans. DTI parameters (mean diffusivity [MD] and fractional anisotropy [FA]) at axial levels of internal capsules and cerebral peduncles along the corticospinal tract (CST) were measured. The study compared the differences of DTI parameters between ALS patients and controls using the Mann-Whitney U test. Diagnostic efficacy of each DTI metric was evaluated using the receiver operating characteristic (ROC) curve. NFs (NFL and pNFH levels in serum and CSF) were measured by enzyme-linked immunosorbent assay. Correlation analyses were conducted between DTI parameters and NFs. Capsule-MD and Peduncle-MD in ALS patients were higher than those in controls; whereas Capsule-FA and Peduncle-FA in ALS patients were lower than those in controls (all, p < 0.05). The area under curve (AUC) was 0.730 for Capsule-FA, 0.828 for Capsule-MD, 0.890 for Peduncle-FA, and 0.896 for Peduncle-MD. Capsule-FA was negatively correlated with CSF-NFL (r = - 0.813, p < 0.001), Serum-NFL (r = - 0.493, p = 0.001), CSF-pNFH (r = - 0.637, p < 0.001), and Serum-pNFH (r = - 0.672, p < 0.001); Peduncle-FA negatively with CSF-NFL (r = - 0.562, p < 0.001), CSF-pNFH (r = - 0.506, p = 0.001), and Serum-pNFH (r = - 0.488, p = 0.001); Peduncle-MD positively with CSF-NFL (r = 0.516, p < 0.001), CSF-pNFH (r = 0.494, p = 0.001). DTI had superior performance in identifying ALS patients and could serve as a reliable predictor. DTI parameters related to neurofilament markers, and Capsule-FA may become a robust surrogate biomarker indicating disease severity and progression rate for ALS patients.

Indexed as

Amyotrophic Lateral SclerosisBiomarkersDiffusion Tensor ImagingNeurofilament ProteinsAdultAgedAnisotropyCase-Control StudiesFemaleHumansMaleMiddle AgedPyramidal TractsROC CurveBiomarkersneurofilament protein Hneurofilament protein LNeurofilament ProteinsAmyotrophic lateral sclerosisDiffusion tensor imagingFractional anisotropyMean diffusivityNeurofilament light chainPhosphorylated neurofilament heavy chain

Identifiers

PMID39548226
PMCPMC11568200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.