Evidence map›Paper›PMID 39548116›Full record

ArticleScientific reports2024

The impact of 9-azaglycophymine and phenylguanidine derivatives on the proliferation of various breast cancer cell lines in vitro and in vivo.

Ibrahim Morgan, Robert Rennert, Robert Berger, Sanja Jelača, Danijela Maksimović-Ivanić, Duško Dunđerović, Sanja Mijatović, Goran N Kaluđerović, Ludger A Wessjohann

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ibrahim MorganDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.ORCID 0000-0002-4032-2691
Robert RennertDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany. robert.rennert@ipb-halle.de.ORCID 0000-0003-3665-6696
Robert BergerDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.ORCID 0009-0000-9939-297X
Sanja JelačaDepartment of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia (IBISS), University of Belgrade, Bulevar Despota Stefana 142, 11108, Belgrade, Serbia.ORCID 0000-0002-9848-6859
Danijela Maksimović-IvanićDepartment of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia (IBISS), University of Belgrade, Bulevar Despota Stefana 142, 11108, Belgrade, Serbia.ORCID 0000-0002-8006-5079
Duško DunđerovićInstitute of Pathology, Faculty of Medicine, University of Belgrade, Dr Subotića 1, 11000, Belgrade, Serbia.ORCID 0000-0001-9708-2089
Sanja MijatovićDepartment of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia (IBISS), University of Belgrade, Bulevar Despota Stefana 142, 11108, Belgrade, Serbia.ORCID 0000-0001-9509-9098
Goran N KaluđerovićDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.ORCID 0000-0001-5168-1000
Ludger A WessjohannDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany. wessjohann@ipb-halle.de.ORCID 0000-0003-2060-8235

Funding

AIP e.V. funded by IB (state of Saxony-Anhalt) through EFRE (Europäischer Fonds für Regionale Entwicklung) US2185Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-47/2023-01/ 200007
6 · The paper itself

Abstract

Quinazolinones, particularly 9-azaglycophymines, and closely related derivatives and precursors were tested in vitro against various breast cancer cell lines representing the major types of breast tumors. Among the 49 compounds tested, azaglycophymine derivative 19 with an electron-withdrawing substituent demonstrated the most significant anti-proliferative effects, with IC

Indexed as

ApoptosisBreast NeoplasmsCell ProliferationMice, Inbred BALB CAnimalsAntineoplastic AgentsCell Line, TumorFemaleGuanidinesHumansMCF-7 CellsMiceQuinazolinonesAntineoplastic AgentsGuanidinesQuinazolinonesAnticancerApoptosisBreast cancerQuinazolineQuinazolinoneStructure-activity-relationship

Identifiers

PMID39548116
PMCPMC11568214

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.