ArticleNature communications2024
Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of neurodevelopmental disorders after fetal topiramate exposure: a systematic review.Frontiers in drug safety and regulation · 2026Pooled it
- Awake craniotomy with functional mapping for recurrent high-grade IDH-mutant glioma during pregnancy: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.Molecular psychiatry · 2026Article
- Vocal and social impairments in songbirds embryonically exposed to an autism risk factor.iScience · 2026Article
- Development of cerebral lateralization in children exposed to fetal antiseizure medications: A prospective cohort study at age 6 years.Epilepsia · 2026Article
- Febrile Seizures and Subsequent Autism Spectrum Disorder: A Nationwide Population-Based Cohort Study.Children (Basel, Switzerland) · 2026Article
- Prenatal antiseizure drug exposure and risk of neurodevelopmental disorders in children: population based cohort study.BMJ (Clinical research ed.) · 2026Article
- Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi-Child Cohort Study.Annals of neurology · 2026Article
- Genetic susceptibility for neurodevelopmental disorders in children born to women with epilepsy.Brain communications · 2026Article
- Pregnancy, baby, and childhood outcomes from using anti-seizure medication during pregnancy.Communications medicine · 2025Article
- Paternal Valproate Use and Neurodevelopmental Disorder and Congenital Malformation Risk in Offspring.JAMA network open · 2025Observational
- Article
- Impact of pregnancy on the treatment and outcomes of glioma: a cohort study.Journal of neuro-oncology · 2025Article
- Seizure Control During Pregnancy vs. Neurodevelopmental Outcomes of Babies - Can We Achieve an Optimal Balance?Indian journal of pediatrics · 2025Article
- Psychotropic prescribing patterns during pregnancy in two South African mental health clinics.Journal of the colleges of medicine of South Africa · 2025Article
- Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes.Nature communications · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
The teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety of other antiseizure medications (ASMs) during pregnancy remains limited. Using routinely collected primary care data from the UK and nationwide Swedish registries to create a cohort of 3,182,773 children, of which 17,495 were exposed to ASMs in pregnancy, we show that those exposed to valproate were more likely to receive a diagnosis of autism, intellectual disability, and ADHD, when compared to children not exposed to ASMs. Additionally, children exposed to topiramate were 2.5 times more likely to be diagnosed with intellectual disability (95% CI: 1.23-4.98), and those exposed to carbamazepine were 1.25 times more likely to be diagnosed with autism (95% CI: 1.05-1.48) and 1.30 times more likely to be diagnosed with intellectual disability (95% CI: 1.01-1.69). There was little evidence that children exposed to lamotrigine in pregnancy were more likely to receive neurodevelopmental diagnoses. While further research is needed, these findings may support considering safer treatment alternatives well before conception when clinically appropriate.
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