Evidence map›Paper›PMID 39548008›Full record

ArticleSurgical endoscopy2025

Inflammation-attenuating effect of carbon dioxide versus room-air environment in a rat laparotomy model.

Petros Ypsilantis, Ioanna Stylianaki, Fotini Papachristou, Panagiotis Papatheodorou, Christos Svoronos, Konstantinos Spyridakis, Michael Margaritis, Ifigenia Ypsilantou, Konstantinos Ypsilantis, Nikolaos Papaioannou and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Petros YpsilantisLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece. pipsil@med.duth.gr.ORCID 0000-0002-7744-3809
Ioanna StylianakiLaboratory of Pathology, Department of Veterinary Medicine, School of Health Sciences, Aristotelion University of Thessaloniki, 54124, Thessaloniki, Greece.
Fotini PapachristouLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Panagiotis PapatheodorouLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Christos SvoronosLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Konstantinos SpyridakisLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Michael MargaritisLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Ifigenia YpsilantouLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Konstantinos YpsilantisLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Nikolaos PapaioannouLaboratory of Pathology, Department of Veterinary Medicine, School of Health Sciences, Aristotelion University of Thessaloniki, 54124, Thessaloniki, Greece.
Anastasios KarayiannakisLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.
Michael PitiakoudisLaboratory of Experimental Surgery and Surgical Research, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Building 12, 68100, Alexandroupolis, Dragana, Greece.

Funding

Special Account for Research Funds of the Democritus University of Thrace, Greece 80216
6 · The paper itself

Abstract

backgroundThe mechanism by which laparoscopic operations induce lower post-operative inflammatory response compared to open surgery was investigated with regard to the effect of the type of gas environment.

methodsRats were subjected to midline laparotomy at either CO

resultsTissue expression of IL-6, TNFα, and NFκΒ was downregulated in the liver and intestine in group CO

conclusionPost-operative local inflammatory response was lower in intra-peritoneal organs of rats subjected to laparotomy at CO

Indexed as

Carbon DioxideLaparotomyAirAnimalsBiomarkersInflammationInterleukin-6KidneyLaparoscopyLiverMaleNF-kappa BRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaBiomarkersCarbon DioxideInterleukin-6NF-kappa BTumor Necrosis Factor-alphaAirCarbon dioxideInflammationPeritoneal cavityRat

Identifiers

PMID39548008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.