Evidence map›Paper›PMID 39547943›Full record

ArticleJournal of hepato-biliary-pancreatic sciences2025

An artificial intelligence-based recognition model of colorectal liver metastases in intraoperative ultrasonography with improved accuracy through algorithm integration.

Maho Takayama, Kyoji Ito, Kenji Karako, Yuichiro Mihara, Shu Sasaki, Akihiko Ichida, Takeshi Takamoto, Nobuhisa Akamatsu, Yoshikuni Kawaguchi, Kiyoshi Hasegawa

Abstract read
In one paragraph

Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maho TakayamaHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kyoji ItoHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kenji KarakoHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuichiro MiharaHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shu SasakiHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Akihiko IchidaHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takeshi TakamotoHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Nobuhisa AkamatsuHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1603-5147
Yoshikuni KawaguchiHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2986-3224
Kiyoshi HasegawaHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8734-740X

Funding

Japan Society for the Promotion of Science 20K20214Japan Surgical Society the 106th annual congress of JSS Memorial Surgical
6 · The paper itself

Abstract

background/purposeContrast-enhanced intraoperative ultrasonography (CE-IOUS) is crucial for detecting colorectal liver metastases (CLM) during surgery. Although artificial intelligence shows potential in diagnostic systems, its application in CE-IOUS is limited.

methodsThis study aimed to develop an automatic tumor detection model using Mask region-based convolutional neural network (Mask R-CNN) for CE-IOUS images. CE-IOUS videos of the CLM from 121 patients were collected, generating ground truth data. A total of 2659 images were obtained. Two models were developed: the basic recognition model (BRM), which was trained on CE-mode images, and the subtraction model (SM), which used images created by a subtraction algorithm that highlighted the differences in pixel values between the basic-mode and CE-mode images. The subtraction algorithm focuses on echogenicity differences. These two models were combined into a combination model (CM), which assessed outcomes using the prediction probabilities from both models.

resultsThe optimal epochs were determined by the maximum area under the curve (AUC), and the thresholds were calculated accordingly. BRM, SM, and CM achieved 89.4%, 86.6%, and 96.5% accuracy, respectively. CM outperformed the individual models, achieving an AUC of 0.99.

conclusionsA novel automated recognition model was developed for accurate CLM detection in CE-IOUS by integrating image- and algorithm-based models.

Indexed as

AlgorithmsArtificial IntelligenceColorectal NeoplasmsLiver NeoplasmsAgedContrast MediaFemaleHumansMaleMiddle AgedNeural Networks, ComputerUltrasonographyContrast Mediacolorectal cancercomputer‐assisted diagnosisliver resectionmachine learningultrasonography

Identifiers

PMID39547943
PMCPMC11780306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.