Evidence map›Paper›PMID 39547233›Full record

ArticleCell metabolism2025

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis.

Jivani M Gengatharan, Michal K Handzlik, Zoya Y Chih, Maureen L Ruchhoeft, Patrick Secrest, Ethan L Ashley, Courtney R Green, Martina Wallace, Philip L S M Gordts, Christian M Metallo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Polyphenol-RichNutrients · 2026
    Article
  3. Sphingolipids and Atherosclerosis.Current atherosclerosis reports · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jivani M GengatharanMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Michal K HandzlikMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Zoya Y ChihMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Maureen L RuchhoeftMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Patrick SecrestDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ethan L AshleyMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Courtney R GreenMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Martina WallaceSchool of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
Philip L S M GordtsDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA.
Christian M MetalloMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. Electronic address: metallo@salk.edu.

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Investigating Syndecan-1 in Hepcidin Regulation and Iron MetabolismR01DK126848 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GORDTS, PHILIP · 2021 to 2025
$3.0M
Non-essential amino acids and sphingolipid diversity in cancer progressionR01CA234245 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI METALLO, CHRISTIAN MICHAEL · 2019 to 2023
$1.9M
NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA234245NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK126848
6 · The paper itself

Abstract

Dietary fat drives the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), particularly through circulating cholesterol and triglyceride-rich lipoprotein remnants. Industrially produced trans-unsaturated fatty acids (TFAs) incorporated into food supplies significantly promote ASCVD. However, the molecular trafficking of TFAs responsible for this association is not well understood. Here, we demonstrate that TFAs are preferentially incorporated into sphingolipids by serine palmitoyltransferase (SPT) and secreted from cells in vitro. Administering high-fat diets (HFDs) enriched in TFAs to Ldlr

Indexed as

AtherosclerosisDiet, High-FatSerine C-PalmitoyltransferaseSphingolipidsAnimalsHumansLipoproteinsLipoproteins, VLDLLiverMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLLipoproteinsLipoproteins, VLDLReceptors, LDLSerine C-PalmitoyltransferaseSphingolipidsSptlc2 protein, mouseatherosclerosislipoproteinmonounsaturated fatty acidmyriocinsphingolipidsphingomyelinSPTLC3trans fatty acidTRL remnantVLDL

Identifiers

PMID39547233
PMCPMC12276992

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.