Evidence map›Paper›PMID 39547223›Full record

ArticleMolecular cell2024

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment.

Anisha R Ramadhin, Shun-Hsiao Lee, Di Zhou, Anita Salmazo, Camila Gonzalo-Hansen, Marjolein van Sluis, Cindy M A Blom, Roel C Janssens, Anja Raams, Dick Dekkers and 8 more

Abstract read
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In one paragraph

Article in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Topology Resetting During Transcription-Coupled Nucleotide Excision Repair.International journal of molecular sciences · 2026
    Review
  4. Article
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  6. Article
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  9. Review
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  14. Review
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  17. Recent progress and future challenges in structure-based protein-protein interaction prediction.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  18. Transcription-Coupled Repair and R-Loop Crosstalk in Genome Stability.International journal of molecular sciences · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Anisha R RamadhinDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Shun-Hsiao LeeDivision of Biochemistry, Netherlands Cancer Institute and Oncode Institute, 1066 CX Amsterdam, the Netherlands.
Di ZhouDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Anita SalmazoInstitute of Science and Technology Austria (ISTA), 3400 Klosterneuburg, Austria.
Camila Gonzalo-HansenDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Marjolein van SluisDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Cindy M A BlomDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Roel C JanssensDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Anja RaamsDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Dick DekkersProteomics Center, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Karel BezstarostiProteomics Center, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Dea SladeDepartment of Medical Biochemistry, Medical University of Vienna, Max Perutz Labs, Vienna Biocenter, 1030 Vienna, Austria.
Wim VermeulenDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Alex PinesDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Jeroen A A DemmersProteomics Center, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands.
Carrie BerneckyInstitute of Science and Technology Austria (ISTA), 3400 Klosterneuburg, Austria.
Titia K SixmaDivision of Biochemistry, Netherlands Cancer Institute and Oncode Institute, 1066 CX Amsterdam, the Netherlands. Electronic address: t.sixma@nki.nl.
Jurgen A MarteijnDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands. Electronic address: j.marteijn@erasmusmc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcription-coupled nucleotide excision repair (TC-NER) efficiently eliminates DNA damage that impedes gene transcription by RNA polymerase II (RNA Pol II). TC-NER is initiated by the recognition of lesion-stalled RNA Pol II by CSB, which recruits the CRL4

Indexed as

DNA DamageDNA RepairProtein Serine-Threonine KinasesRNA Polymerase IITranscription Factor TFIIHTranscription, GeneticUbiquitinationCarrier ProteinsCryoelectron MicroscopyDNA HelicasesDNA Repair EnzymesExcision RepairHEK293 CellsHeLa CellsHumansPoly-ADP-Ribose Binding ProteinsCarrier ProteinsDNA HelicasesDNA Repair EnzymesERCC6 protein, humanIL17RB protein, humanPoly-ADP-Ribose Binding ProteinsProtein Serine-Threonine KinasesReceptors, Interleukin-17RNA Polymerase IITranscription Factor TFIIHUVSSA protein, humanCSACSBDNA damageDNA repairRNA polymerase IISTK19TC-NERTFIIHtranscription-coupled nucleotide excision repairUVSSA

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.