Evidence map›Paper›PMID 39546997›Full record

ArticleJournal of critical care2025

Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19.

Laurence W Busse, J Pedro Teixeira, Christopher L Schaich, Caitlin C Ten Lohuis, Nathan D Nielsen, Jeffrey M Sturek, Lisa H Merck, Wesley H Self, Michael A Puskarich, Akram Khan and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Laurence W BusseDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA; Emory Critical Care Center, Emory Healthcare, Atlanta, GA, USA.
J Pedro TeixeiraDivision of Nephrology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA. Electronic address: jteixeira@salud.unm.edu.
Christopher L SchaichHypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Caitlin C Ten LohuisEmory Critical Care Center, Emory Healthcare, Atlanta, GA, USA.
Nathan D NielsenDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA; Section of Transfusion Medicine and Therapeutic Pathology, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Jeffrey M SturekDivision of Pulmonary and Critical Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Lisa H MerckDepartment of Emergency Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Wesley H SelfDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael A PuskarichDepartment of Emergency Medicine, Hennepin Healthcare, Minneapolis, MN, USA.
Akram KhanDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health and Science University, Portland, OR, USA.
Matthew W SemlerVanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ari MoskowitzDivision of Critical Care, Montefiore Medical Center, The Bronx, NY, USA.
David N HagerDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Abhijit DuggalDepartment of Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA.
Todd W RiceVanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Adit A GindeDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Brian R TiffanyChandler Regional Medical Center, Chandler, AZ, USA.
Nicole M IovineUniversity of Florida Health, Gainesville, FL, USA.
Peter ChenWomen's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Basmah SafdarDepartment of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.
Kevin W GibbsDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ali JavaheriDepartment of Medicine, Washington University, Saint Louis, MO, USA.
Marjolein de WitDepartment of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Michelle S HarkinsDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Meghan M JolyVanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Sean P CollinsDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
ACTIV-4 Host Tissue Investigators

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cardiac Autonomic Function, Cognitive Performance, and Neurocognitive OutcomesK01AG073581 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SCHAICH, CHRISTOPHER · 2021 to 2024
$384k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS OT2 HL156812NIA NIH HHS K01 AG073581
6 · The paper itself

Abstract

backgroundPlasma dipeptidyl peptidase-3 (DPP3) and renin levels are associated with organ dysfunction and mortality. However, whether these biomarkers are associated with the subsequent onset of shock in at-risk patients is unknown.

methodsUsing plasma samples collected from participants enrolled in the fourth Accelerating COVID-19 Therapeutic Interventions and Vaccines Host Tissue platform trial, we measured DPP3 and renin in 184 subjects hospitalized with acute hypoxemia from COVID-19 without baseline vasopressor requirement. We calculated the odds ratio of development of shock (defined as the initiation of vasopressor therapy) by Day 28 based on Day 0 DPP3 and renin levels.

resultsSubjects with DPP3 above the median had a significantly higher incidence of vasopressor initiation within 28 days (28.4 % vs. 16.7 %, p = 0.031) and higher 28-day mortality (25.0 % vs. 6.7 %, p < 0.001). After adjusting for covariables, DPP3 above the median was associated with shorter time to vasopressor initiation, greater 28-day mortality, fewer vasopressor-free days, and greater odds of a hypotensive event over 7 days. Significant associations were not observed for renin.

conclusionsIn patients hospitalized with COVID-19 and hypoxemia without baseline hypotension, higher baseline plasma levels of DPP3 but not renin were associated with increased risk of subsequent shock and death.

Indexed as

BiomarkersCOVID-19HypoxiaReninSARS-CoV-2Adaptive Clinical Trials as TopicAgedDipeptidyl-Peptidases and Tripeptidyl-PeptidasesFemaleHumansMaleMiddle AgedShockVasoconstrictor AgentsBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDPP3 protein, humanReninVasoconstrictor AgentsBiomarkerClinical trial registered on June 10, 2021, on www.clinicaltrials.gov (NCT04924660).COVID-19Dipeptidyl peptidase-3ReninSeptic shock

Identifiers

PMID39546997
PMCPMC11697573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.