ArticleDevelopmental cognitive neuroscience2024
Disentangling the unique contributions of age, pubertal stage, and pubertal hormones to brain structure in childhood and adolescence.
Article in Developmental cognitive neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Individual differences reveal distinct age and pubertal contributions to the refinement of the functional cortical hierarchy during adolescence.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal changes in T1w/T2w estimates of cortical myelin with age and pubertal timing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health.Communications biology · 2025Article
- Sex and age differences on how testosterone relates to brain activity during working memory among adolescents and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Iron Deficiency Without Anemia and Reduced Basal Ganglia Iron Content in Youths.JAMA network open · 2025Article
- Disentangling the unique associations of age, pubertal stage, and pubertal hormones with white matter microstructure in childhood and adolescence.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
8 authors.
Funding
Abstract
Puberty and associated changes in pubertal hormones influence structural brain development. Hormones such as dehydroepiandrosterone (DHEA) and progesterone remain understudied, and it remains unclear how these aspects of puberty contribute uniquely to structural brain development. We used the Human Connectome Project in Development cross-sectional sample of 1304 youth (aged 5-21 years) to investigate unique contributions of sex, age, pubertal stage, DHEA, testosterone, estradiol, and progesterone to cortical thickness, surface area, and subcortical volume development within functionally-relevant networks. Sex and age explain the most unique variance in all three aspects of structural development. Pubertal stage and pubertal hormones uniquely contribute more to cortical surface area, compared to thickness. Among the pubertal hormones, progesterone contributed unique variance to surface area in the default mode network, as well as to thickness in the orbito-affective network. Pubertal mechanisms also contributed unique variance to subcortical volumes. This demonstrates unique relations of understudied pubertal hormones to brain structure development and may help understand risk for psychopathology.
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