Evidence map›Paper›PMID 39546376›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2025

Snus and Cardiometabolic Health Markers Among Swedish Young Adults.

Anna Zettergren, Niklas Andersson, Göran Pershagen, Christian Lindh, Antonios Georgelis, Inger Kull, Erik Melén, Sandra Ekström, Petter Ljungman, Anna Bergström

Abstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna ZettergrenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-9145-9444
Niklas AnderssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Christian LindhDivision of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Antonios GeorgelisInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Inger KullDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Erik MelénDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Sandra EkströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2060-8190
Petter LjungmanInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7815-2632
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Funding

Formas 2016-01646Gates Foundation INV-009284Karolinska InstitutetSwedish Asthma and Allergy Research Foundation and Region StockholmSwedish Environmental Protection Agency NV-00175-15Swedish Environmental Protection Agency NV-09284-13Swedish Heart-Lung FoundationSwedish Research Council 2016-03086Swedish Research Council 2018-02524Swedish Research Council 2020-02170Swedish Research Council for Health, Working Life and Welfare 2017-00526
6 · The paper itself

Abstract

introductionSnus is suggested as a risk factor for cardiometabolic disease, but little is known about health effects in young populations, particularly in women. We aimed to investigate associations between snus and cardiometabolic health markers among young men and women. AIMS AND

methodsThis study was conducted within the BAMSE (Swedish acronym for Children, Allergy, Environment, Stockholm, Epidemiology) birth cohort and included participants followed up around 24 years (n = 2256) and 26 years (n = 1011). Snus use was assessed at 24 years by questionnaires. Cardiometabolic health markers were recorded at clinical examinations at 24 and 26 years. Associations between snus use and cardiometabolic markers were assessed by multivariable linear regression.

resultsSnus was used by 6.4% (n = 81) among women and 21.9% (n = 219) among men. Compared to no tobacco use, daily exclusive snus use among women at 24 years was associated with higher body mass index (BMI) (adjusted β: 1.93 kg/m2, 95% confidence interval [CI] = 0.54, 3.33) and waist circumference (WC) (aβ: 3.80 cm, 95% CI = 0.41, 7.18) at 24 years, and with higher BMI (aβ: 2.73 kg/m2, 95% CI = 0.53 to 4.93) at 26 years. Among men, using ≥4 cans/week was associated with increased BMI (aβ: 2.48 kg/m2, 95% CI = 0.73, 4.24) and a tendency toward increased body fat (aβ: 2.31%, 95% CI = -0.53, 5.14) at 26 years. Snus use was not associated with glycemic status or blood pressure.

conclusionsOur results suggest that snus is associated with increased BMI, and possibly other measures of adiposity, among young women and heavy-using young men. Given the cross-sectional study design, the results should be interpreted with caution. IMPLICATIONS: We found cross-sectional associations between snus use and measures of increased adiposity in a cohort of Swedish young adults, including BMI and WC among women and BMI among heavy snus-using men. We did not find associations between snus use and body fat %, glycemic status, or blood pressure. This is one of few studies to investigate the health effect of snus among both women and men as well as cardiometabolic health markers in young adults. Given the recent trends of increased snus use among young adults, our findings highlight the need for further research on snus on cardiometabolic health.

Indexed as

Cardiovascular DiseasesAdultBiomarkersBody Mass IndexCardiometabolic Risk FactorsCohort StudiesFemaleHumansMaleRisk FactorsSurveys and QuestionnairesSwedenWaist CircumferenceYoung AdultBiomarkers

Identifiers

PMID39546376
PMCPMC12095809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.