Evidence map›Paper›PMID 39546143›Full record

GuidelineHepatology international2024

Non-cirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and management.

Akash Shukla, Don C Rockey, Patrick S Kamath, David E Kleiner, Ankita Singh, Arun Vaidya, Abraham Koshy, Ashish Goel, A Kadir Dökmeci, Babulal Meena and 28 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Identification of Prognostic Factors and Regulatory Pathways in Porto-Sinusoidal Vascular Disorder.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. [Emphasis on the etiological diagnosis and management of non-cirrhotic portal hypertension].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Challenges in the management of vascular liver disorders in women in the reproductive period.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. [Research progress on animal models relevant to porto-sinusoidal vascular disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Akash ShuklaDepartment of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India.
Don C RockeyDigestive Disease Research Center, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 803, MSC 623, Charleston, SC, 29425, USA.
Patrick S KamathMayo Clinic College of Medicine and Science, Rochester, MN, USA.
David E KleinerNational Cancer Institute, Bethesda, MD, USA.
Ankita SinghDepartment of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India.
Arun VaidyaDepartment of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India.
Abraham KoshyDepartment of Gastroenterology, VPS Lakeshore Hospital, Kochi, Kerala, India.
Ashish GoelDepartment of Hepatology, CMC, Vellore, India.
A Kadir DökmeciDepartment of Medicine, Ankara University School of Medicine, Ankara, Turkey.
Babulal MeenaDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Cyriac Abby PhilipsDepartment of Clinical and Translational Hepatology, The Liver Institute, Rajagiri Hospital, Aluva, Kerala, India.
Chhagan Bihari SharmaDepartment of Pathology, Institute of Liver and Biliary Sciences, New Delhi, Delhi, India.
Diana A PayawalFatima University Medical Center Manila, Manila, Philippines.
Dong Joon KimDepartment of Internal Medicine, Hallym University College of Medicine, Seoul, South Korea.
Gin-Ho LoDepartment of Medical Research, E-Da Hospital, Kaohsiung, School of Medicine for International Students, I-Shou University, 1, Yi-Da Road, Kaohsiung, 824, Taiwan.
Guohong HanDepartment of Liver Disease and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
Huma QureshiDoctor's Plaza, Clifton, Karachi, Pakistan.
Ian R WanlessDepartment of Pathology, Dalhousie University, Halifax, Canada.
Jidong JiaLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, Mainland, China.
Jose D SollanoDepartment of Medicine, University of Santo Tomas, Manila, Philippines.
Mamun Al MahtabDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Mark Dhinesh MuthiahYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mark W SonderupDivision of Hepatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Mendez Sanchez NahumFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Mohamed Ismail Bin MericanBoard of Governors, MAHSA University, Jenjarom, Malaysia.
Necati Ormeciİstanbul Health and Technology University, Istanbul, Turkey.
Norifumi KawadaDepartment of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-Ku, Osaka, 545-8585, Japan.
Rajender ReddyDivision of Gastroenterology and Hepatology, 2 Dulles, Liver Transplant Office, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
R K DhimanDepartment of Hepatology, PGIMER, Chandigarh, India.
Rino GaniDivision of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.
Saeed S HameedDepartment of Medicine, Aga Khan University and Hospital, Stadium Road, Karachi, 74800, Pakistan.
Sidharth HarindranathDepartment of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India.
Wasim JafriDepartment of Medicine, Aga Khan University and Hospital, Stadium Road, Karachi, 74800, Pakistan.
Xiaolong QiCenter of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Nanjing, China.
Yogesh Kumar ChawlaDepartment of Hepatology and Gastroenterology, Kalinga Institute of MedicalSciences, KIIT University, Bhubaneshwar, India.
Yoshihiro FuruichiDepartment of Clinical Laboratory and Endoscopy, Tokyo Women's Medical University, Adachi Medical Center, Tokyo, Japan.
Ming-Hua ZhengMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Shiv Kumar SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. sksarin@ilbs.in.ORCID http://orcid.org/0000-0002-0544-5610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the Asian Pacific Association for the Study of the Liver (APASL) published guidelines on non-cirrhotic portal fibrosis/idiopathic portal hypertension in 2007, there has been a surge in new information, especially with the introduction of the term porto-sinusoidal vascular disorder (PSVD). Non-cirrhotic intra-hepatic causes of portal hypertension include disorders with a clearly identifiable etiology, such as schistosomiasis, as well as disorders with an unclear etiology such as non-cirrhotic portal fibrosis (NCPF), also termed idiopathic portal hypertension (IPH). This entity is being increasingly recognized as being associated with systemic disease and drug therapy, especially cancer therapy. An international working group with extensive expertise in portal hypertension was assigned with formulating consensus guidelines to clarify the definition, diagnosis, histological features, natural history, and management of NCPF/IPH, especially in the context of PSVD. The guidelines were prepared based on evidence from existing published literature. Whenever there was paucity of evidence, expert opinion was included after detailed deliberation. The goal of this manuscript, therefore, is to enhance the current understanding and help create global consensus on the issues surrounding NCPF/IPH.

Indexed as

Hypertension, PortalHumansIdiopathic Noncirrhotic Portal HypertensionLiver CirrhosisAPASL consensusIdiopathic non-cirrhotic portal hypertensionIncomplete septal cirrhosisINCPHNCPFNCPHNodular regenerative hyperplasiaNon-cirrhotic portal hypertensionObliterative portal venopathyPortal hypertensionPorto-sinusoidal vascular diseaseVariceal bleed

Identifiers

PMID39546143

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.