Evidence map›Paper›PMID 39546128›Full record

ArticleMolecular biology reports2024

LPS-induced neuroinflammation induces changes in the transcriptional profile of members of the CoRest repressive complex in the hippocampus.

Liebert Bernardes Carvalho, Kusai Baroudi, Cleiton França, Arila Adorno Scorzafava Gonçalves, Maria Martha Bernadi, Rodrigo Augusto Foganholi da Silva

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liebert Bernardes CarvalhoPostgraduate Program in Health Sciences, University of Taubaté, Taubaté, São Paulo, SP, Brazil.
Kusai BaroudiDepartment of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Cleiton FrançaCEEpiRG - Center for Epigenetic Study and Genic Regulation, Program in Environmental and Experimental Pathology, Paulista University - UNIP, São Paulo, SP, Brazil.
Arila Adorno Scorzafava GonçalvesCEEpiRG - Center for Epigenetic Study and Genic Regulation, Program in Environmental and Experimental Pathology, Paulista University - UNIP, São Paulo, SP, Brazil.
Maria Martha BernadiCEEpiRG - Center for Epigenetic Study and Genic Regulation, Program in Environmental and Experimental Pathology, Paulista University - UNIP, São Paulo, SP, Brazil.
Rodrigo Augusto Foganholi da SilvaPostgraduate Program in Health Sciences, University of Taubaté, Taubaté, São Paulo, SP, Brazil. dasilva.rodrigo.a@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 301498/2022-9Fundação de Amparo à Pesquisa do Estado de São Paulo , Brasil 2023/12852-3
6 · The paper itself

Abstract

The action of Corepressor for Element Silencing Transcription Factor 1 (CoREST) is primarily related to neural fate decisions. However, the molecular mechanisms linking neuroinflammation to the histone modifying complex remain unclear. CoREST is a hub for several cofactors that play important roles in epigenetic remodeling and transcriptional regulation. It allows us to question their functions during the inflammatory response in the Central Nervous System. The impact of LPS-induced neuroinflammation on the transcriptional epigenetic control of members with CoRest repressive complex in the hippocampus was investigated. Characterizing the basal transcriptional profile in the hippocampus of members with CoREST repressive complex showed that the Rcor3 is the most expressed gene, and the Rcor2 is the least expressed one. It was also demonstrated that the levels of Lsd1, CoREST1 (Rcor1), and CoREST2 (Rcor2) transcripts increased in the hippocampus after LPS i.p. administration, while for CoREST3 (Rcor3), no significant difference was observed. A significant increase was noticed in the percentages of the 5-meC mark (Hypermethylation) for the Rcor1 and Lsd1 genes with a positive Pearson correlation between methylation and expression. However, the correlation was directly proportional, ruling out DNA methylation as the main mechanism in transcriptional control.

Indexed as

Co-Repressor ProteinsHippocampusHistone DemethylasesLipopolysaccharidesAnimalsDNA MethylationEpigenesis, GeneticGene Expression RegulationInflammationMaleMiceNerve Tissue ProteinsNeuroinflammatory DiseasesRepressor ProteinsTranscriptomeCo-Repressor ProteinsHistone DemethylasesKDM1a protein, mouseLipopolysaccharidesNerve Tissue ProteinsRcor2 protein, mouseRepressor ProteinsCoRESTDNA methylationNeuroepigeneticsNeuroinflammation

Identifiers

PMID39546128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.