Evidence map›Paper›PMID 39546082›Full record

Observational studyClinical and experimental nephrology2025

Clinical characteristics of monoclonal immunoglobulin-associated renal disease: a retrospective cohort study.

Toshiyuki Narimiya, Hiroki Hayashi, Soshiro Ogata, Shigeo Hara, Akinao Okamoto, Kazuo Takahashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Akihiro Tomita and 2 more

Abstract readObservational StudyComparative Study
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In one paragraph

Observational study in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Toshiyuki NarimiyaDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Hiroki HayashiDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. hhayashi@fujita-hu.ac.jp.ORCID http://orcid.org/0000-0002-6866-890X
Soshiro OgataDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Shigeo HaraDepartment of Pathology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.
Akinao OkamotoDepartment of Hematology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Kazuo TakahashiDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Shigehisa KoideDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Daijo InagumaDepartment of Nephrology, Fujita Health University Bantane Hospital, Nagoya, Aichi, Japan.
Midori HasegawaDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Akihiro TomitaDepartment of Hematology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Yukio YuzawaDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Naotake TsuboiDepartment of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Funding

Japan Society for the Promotion of Science London JP 20K08600
6 · The paper itself

Abstract

introductionClinical epidemiological data on monoclonal gammopathy of renal significance (MGRS) are lacking. In this retrospective observational study, MGRS was compared with B-cell or plasma cell malignancies (BCM/PCM) with renal involvement to clarify differences in their clinical features.

methodsAmong the 1408 renal biopsies performed at our hospital, 25 MGRS and 18 BCM/PCM patients were identified. We investigated baseline characteristics and hematologic parameters of MGRS in reference to BCM/PCM using multivariable analysis. Cox proportional hazards analysis was performed for end-stage kidney disease (ESKD) and all-cause mortality.

resultsComparing the MGRS with the BCM/PCM, mean differences in creatinine level, estimated glomerular filtration rate, and clonal bone marrow plasma cell percentage were - 2.76 mg/dL, 27.72 mL/min/1.73 m

conclusionsThe clinical characteristics of MGRS and BCM/PCM with monoclonal immunoglobulin-associated renal disease are disparate. Understanding these differences is crucial for developing tailored clinical approaches and therapeutic strategies to improve patient outcome.

Indexed as

KidneyKidney DiseasesParaproteinemiasAcute Kidney InjuryAgedBiopsyFemaleGlomerular Filtration RateHumansKidney Failure, ChronicMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRetrospective StudiesRisk FactorsClone-directed therapyEnd-stage renal diseaseMGRS-associated renal diseaseMonoclonal gammopathy of renal significance

Identifiers

PMID39546082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.