ArticleJournal of the American College of Cardiology2025
Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease.
Article in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of exercise interventions on cognitive function in sedentary adults: a systematic review and network meta-analysis.Frontiers in public health · 2026Pooled it
- Assessment of Wrist-Worn Activity Tracker Accuracy for Measuring Sedentary Behavior in Outpatients With Cardiovascular Disease: Validation Study.JMIR cardio · 2026Article
- 24h movement behaviours in university students compared to working age and older adults: wearable-based evidence and cardiometabolic health implications.BMC medicine · 2026Article
- Micro-bursts matter: vigorous intermittent lifestyle physical activity and risk of common brain disorders in a prospective cohort study.The international journal of behavioral nutrition and physical activity · 2026Article
- Article
- [Update coronary artery disease].Innere Medizin (Heidelberg, Germany) · 2026Review
- Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Acute Effects of Interrupting Prolonged Sitting on Glucose, Insulin and Lipid Metabolism in Healthy Populations: A Three-Level Meta-Analysis.Metabolites · 2026Review
- Accelerometer-measured physical activity fragmentation and incident cardiovascular diseases: a prospective cohort study.Nutrition journal · 2026Article
- Association Between Prolonged Sedentary Time and Elevated High-sensitivity C-reactive Protein Among Korean Adults Aged 65 Years or Older: KNHANES 2022.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Sustained Reduction in Cardiopulmonary Fitness in Long COVID: A Report from the RECOVER-adult Cohort Study.JACC. Advances · 2026Article
- Association between sarcopenia and mortality in patients with osteoarthritis.Clinical rheumatology · 2026Article
- Epidemiology of cardiovascular-kidney-metabolic syndrome.Nature reviews. Nephrology · 2026Review
- Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health.JACC. Advances · 2026Article
- Bidirectional reallocations of sitting time, physical activity, and sleep in relation to risk of all-cause mortality and cardiovascular disease: An analysis of the Prospective Urban Rural Epidemiology (PURE)-China cohort study.Journal of sport and health science · 2026Article
- Daily steps offset risks of sedentary behavior in the All of Us research program.Nature communications · 2026Article
- Associations between body image changes and modifiable behavioral variables among university students in the context of COVID-19 pandemic.Scientific reports · 2026Article
- Exercise and physical activity interventions in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Review
- Accelerometer-derived "weekend warrior" physical activity pattern and all-cause mortality in individuals with kidney stones: a prospective cohort study.Frontiers in nutrition · 2026Article
- Sex differences in the associations of multidomain risk factor profiles with incident major adverse cardiovascular events.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundBeyond serving as a marker for insufficient physical activity, sedentary behavior may directly affect future cardiovascular (CV) disease risk.
objectivesThis study sought to examine associations between accelerometer-measured sedentary behavior with risk of specific CV outcomes, including potential relations with moderate to vigorous physical activity (MVPA).
methodsAmong participants of the UK Biobank prospective cohort study, we fit Cox models adjusted for demographic and lifestyle factors to assess associations between accelerometer-measured daily sedentary time with incident atrial fibrillation (AF), myocardial infarction (MI), heart failure (HF), and CV mortality. We assessed the potential effect of MVPA on associations between sedentary time and CV disease by including MVPA as an adjustment variable, as well as performing subgroup analyses stratified at the guideline-recommended MVPA threshold (ie, ≥150 min/wk). We then performed compositional analyses to estimate the effects of reallocating sedentary time to other activities.
resultsAmong 89,530 individuals (age 62 ± 8 years, 56.4% women) undergoing 1 week of accelerometry, median sedentary time was 9.4 h/d (Q1-Q3: 8.2-10.6). In multivariable models, using the second quartile (8.2-9.4 h/d) as a referent, sedentary time in the top quartile (>10.6 h/d) was associated with greater risks of HF (HR: 1.45; 95% CI: 1.28-1.65) and CV mortality (HR: 1.62; 95% CI: 1.34-1.96), with an inflection of risk at 10.6 h/d. Higher sedentary time was also associated with greater risks of incident AF (HR: 1.11; 95% CI: 1.01-1.21) and MI (HR: 1.15; 95% CI: 1.00-1.32), with an approximately linear relation. Associations with HF and CV mortality persisted among individuals meeting guideline-recommended MVPA levels. Among individuals with >10.6 h/d of sedentary time, reallocating sedentary behavior to other activities substantially reduced the excess CV risk conferred by sedentary behavior (eg, 30-minute decrease in sedentary time for HF: HR: 0.93; 95% CI: 0.90-0.96), even among individuals meeting guideline-recommended MVPA (HR: 0.93; 95% CI: 0.87-0.99).
conclusionsSedentary behavior is broadly associated with future adverse CV outcomes, with particularly prominent effects on HF and CV mortality, where risk inflected at approximately 10.6 h/d. Although guideline-adherent MVPA partially mitigates excess risk, optimizing sedentary behavior appears to be important even among physically active individuals.
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