ArticleJournal of biomechanical engineering2025
Effect of Collagen Fiber Tortuosity Distribution on the Mechanical Response of Arterial Tissues.
Article in Journal of biomechanical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Bulk density-calibrated fiber networks reveal local weakness as the driver of protease-dependent aortic failure.International journal of engineering science · 2026Article
- Quantifying Local Strain Field and Deformation in Active Contraction of Bladder Using a Pretrained Transformer Model: A Speckle-Free Approach.Results in engineering · 2026Article
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.Science advances · 2025Article
- Load Transfer along Continuous Collagen Fibers Reduces the Importance of Wall Thickness Variations.ArXiv · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This study investigated the effect of collagen fiber tortuosity distribution on the biomechanical failure and prefailure properties of arterial wall tissue. An in-silico model of the arterial wall was developed using data obtained from combined multiphoton microscopy imaging and uni-axial tensile testing. Layer-dependent properties were prescribed for collagen, elastin, and ground substance. Collagen fibers were modeled as discrete anisotropic elements, while elastin and ground substance were modeled as homogeneous isotropic components. Our parametric analysis, using a finite element approach, revealed that different parameters of collagen fibers tortuosity distribution significantly influence both prefailure and failure biomechanical properties. Increased fiber tortuosity improved the tissue strength whereas the dispersion in the tortuosity distribution reduced it. This study provides novel insights into the structural-mechanical interdependencies in arterial walls, offering potential targets for clinical assessments and therapeutic interventions aimed at mitigating rupture risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.