Evidence map›Paper›PMID 39545682›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment.

Deniz Y Dogan, Isabelle Hornung, Mariateresa Pettinato, Alessia Pagani, Ulrike Baschant, Guiscard Seebohm, Lorenz C Hofbauer, Laura Silvestri, Martina Rauner, Andrea U Steinbicker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Iron overload induced by ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in normal mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Article
  3. Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deniz Y DoganDepartment of Anesthesia, Intensive Care and Pain Medicine, Goethe University Frankfurt, Frankfurt, Germany.ORCID https://orcid.org/0009-0009-8783-6823
Isabelle HornungDepartment of Anesthesia, Intensive Care and Pain Medicine, Goethe University Frankfurt, Frankfurt, Germany.ORCID https://orcid.org/0009-0001-3221-3815
Mariateresa PettinatoRegulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0000-0002-3259-4865
Alessia PaganiRegulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0000-0002-9566-0233
Ulrike BaschantDepartment of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0002-6862-1650
Guiscard SeebohmIfGH- Cellular Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Münster, Germany.ORCID https://orcid.org/0000-0001-9303-5373
Lorenz C HofbauerDepartment of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0002-8691-8423
Laura SilvestriRegulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0000-0002-8726-9808
Martina RaunerDepartment of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0002-4067-6799
Andrea U SteinbickerDepartment of Anesthesia, Intensive Care and Pain Medicine, Goethe University Frankfurt, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-5237-961X

Funding

Deutsche Forschungsgemeinschaft (DFG) FOR5146
6 · The paper itself

Abstract

Osteopenia is frequently observed in patients with iron overload, especially in those with HFE-dependent hereditary hemochromatosis (HH). Interestingly, not all mouse models of HH show bone loss, suggesting that iron overload alone may not suffice to induce bone loss. In this study, the bone phenotypes of Hjv

Indexed as

Disease Models, AnimalHemochromatosisHemochromatosis ProteinActivin Receptors, Type IActivin Receptors, Type IIAnimalsBone and BonesFemaleGPI-Linked ProteinsIron OverloadMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeSex FactorsActivin Receptors, Type IActivin Receptors, Type IIAcvr1 protein, mouseAcvrl1 protein, mouseGPI-Linked ProteinsHemochromatosis ProteinHJV protein, mouse

Identifiers

PMID39545682
PMCPMC11698015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.