Evidence map›Paper›PMID 39545610›Full record

ArticleFuture oncology (London, England)2024

Adjuvant chemoradiotherapy plus PD-1 inhibitor for pN3 gastric cancer: a randomized, multicenter, Phase III trial.

Wang Yang, Menglong Zhou, Guichao Li, Changming Zhou, Lei Wang, Fan Xia, Hui Zhang, Lijun Shen, Yan Wang, Juefeng Wan and 3 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Future oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wang YangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Menglong ZhouDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Guichao LiDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Changming ZhouDepartment of Oncology, Shanghai Medical College, Fudan University.
Lei WangDepartment of Oncology, Shanghai Medical College, Fudan University.
Fan XiaDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Hui ZhangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Lijun ShenDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Yan WangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Juefeng WanDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Yaqi WangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.
Guangfa ZhaoDepartment of Oncology, Shanghai Medical College, Fudan University.
Zhen ZhangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center.ORCID 0000-0001-7825-2679

Funding

National Natural Science Foundation of China No. 82272732Shanghai Leading Talents Program No. LJ097
6 · The paper itself

Abstract

D2 surgery followed by adjuvant chemotherapy has been established as the standard of care for patients with locally advanced gastric cancer in Asian countries. However, its efficacy is still unsatisfactory, especially for pathological N3 disease. The RACING trial is a randomized, multicenter, Phase III trial designed to compare the efficacy and safety of chemotherapy alone versus chemotherapy in combination with PD-1 inhibitor and radiotherapy in patients with pN3 gastric or gastroesophageal junction adenocarcinoma. A total of 433 patients will be assigned at a 1:1 ratio to the two arms. The primary end point is the 3-year disease-free survival rate. The secondary end points include the 3-year overall survival rate, 3-year local recurrence-free survival rate, treatment-related adverse events and quality of life.

Indexed as

AdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapy, AdjuvantImmune Checkpoint InhibitorsStomach NeoplasmsAdultAgedClinical Trials, Phase III as TopicEsophagogastric JunctionFemaleHumansMaleMiddle AgedMulticenter Studies as TopicNeoplasm StagingProgrammed Cell Death 1 ReceptorImmune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 Receptoradjuvantgastric cancerlocally advancedPD-1 inhibitorradiotherapy

Identifiers

PMID39545610
PMCPMC11776863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.