Evidence map›Paper›PMID 39545489›Full record

ArticleGenome biology and evolution2024

AncestryPainter 2.0: Visualizing Ancestry Composition and Admixture History Graph.

Shuanghui Chen, Chang Lei, Xiaohan Zhao, Yuwen Pan, Dongsheng Lu, Shuhua Xu

Abstract read
In one paragraph

Article in Genome biology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuanghui ChenState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0002-0905-5492
Chang LeiState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0009-0006-1261-9101
Xiaohan ZhaoState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0002-4556-8666
Yuwen PanKey Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0003-0342-4872
Dongsheng LuKey Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-8348-5159
Shuhua XuState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0002-1975-1002

Funding

CFFF Computing Platform and the Human Phenome Data Center of Fudan UniversityNational Key Research and Development Program of China 2023YFC2605400National Natural Science Foundation of China 32288101Office of Global PartnershipsShanghai Science and Technology Commission Program 23JS1410100
6 · The paper itself

Abstract

The earlier version of AncestryPainter is a Perl program that displays the ancestry composition of numerous individuals using a rounded graph. Motivated by the requests of users in practical applications, we updated AncestryPainter to version 2.0 by coding in an R package and improving the layout, providing more options and compatible statistical functions for graphing. Apart from improving visualization functions per se in this update, we added an extra graphing module to visualize genetic distance through radial bars of varying lengths surrounding a core. Notably, AncestryPainter 2.0 allows for multiple pie charts at the center of the graph to display the ancestry composition of more than one target population and implements a method admixture history graph to infer the admixture sequence of multiple ancestry populations. We validated the six admixture history graph metrics using both simulated and real data and implemented a Pearson coefficient-based metric with the best performance in AncestryPainter 2.0. Furthermore, a statistical module was implemented to merge ancestry proportion matrices. AncestryPainter 2.0 is freely available at https://github.com/Shuhua-Group/AncestryPainterV2 and https://pog.fudan.edu.cn/#/Software.

Indexed as

Genetics, PopulationGenome, HumanSoftwareDatasets as TopicHuman GeneticsHumansadmixture history graphancestry compositiongenetic distancepopulation geneticsvisualization

Identifiers

PMID39545489
PMCPMC11604083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.