Observational studyThe Journal of clinical endocrinology and metabolism2025
Cognitive Function in Individuals with Chronic Hypoparathyroidism-A Prospective Observational Study.
Observational study in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Patient-reported outcomes in palopegteriparatide-treated adults with hypoparathyroidism: PaTH Forward trial extension.The Journal of clinical endocrinology and metabolism · 2026Trial
- Adult-onset pseudohypoparathyroidism type 1B diagnosed by methylation analysis: A case report and diagnostic considerations.Medicine · 2026Article
- Neural plasticity impairment in chronic post-surgical hypoparathyroidism: a cross-sectional and prospective pilot study.Endocrine connections · 2026Article
- Development and reliability and validity test of the body image and social function scale for patients after thyroid cancer surgery.Asia-Pacific journal of oncology nursing · 2025Article
- Adaptation and validation of the French version of the Hypoparathyroid Patient Questionnaire 28 (HPQ28) in the ComPaRe-Epi-Hypo e-cohort.JBMR plus · 2025Article
- Pseudohypoparathyroidism Presenting With Recurrent Twitching: Challenges Making a Diagnosis in a Low-Resource Environment.Case reports in endocrinology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objective"Brain fog" is a frequently reported, distressing experience among individuals with chronic hypoparathyroidism, characterized by reduced concentration and reduced ability to perform day-to-day tasks. However, evidence linking chronic hypoparathyroidism to cognitive impairment is limited and inconsistent. This study aimed to explore cognitive function in these patients using a validated neurocognitive test battery, compare results with a matched healthy control group, and analyze the frequency of cognitive impairment based on normative data.
methodsThe participants' cognitive performance was tested using a cognitive test battery, including the Trail Making Test A/B, the Color-Word Interference Test, and the California Verbal Learning Test. These tests were used to evaluate the cognitive domains of attention and processing speed, verbal learning and memory, and executive function. In total, 30 individuals with hypoparathyroidism and 30 healthy controls were included.
resultsTwenty-four patients were women (80.0%), with a median age of 44.5 ± 13.1 and a median disease duration of 8.7 years (±5.3). Individuals with chronic hypoparathyroidism showed poorer cognitive performance in attention and processing speed [F(1,57) = 8.65, P = .005*, η2 = 0.13] compared to healthy controls. A significantly higher percentage of patients had cognitive deficits in both attention and processing speed (56.7% vs 3.3%) and executive function (60.0% vs 16.7%).
conclusionThis study provides evidence that cognitive dysfunction, particularly in attention and processing speed, is common in chronic hypoparathyroidism. Recognizing cognitive impairment in these patients is crucial, especially when discussing workability. Neuropsychological training as an adjunct therapy strategy may be beneficial in managing these cognitive deficits.
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