Evidence map›Paper›PMID 39545365›Full record

SynthesisNutrition reviews2025

Effect of Nutrition Education During Pregnancy on Iron-Folic Acid Supplementation Compliance and Anemia in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.

Melaku Tadege Engidaw, Patricia Lee, Gelana Fekadu, Prasenjit Mondal, Faruk Ahmed

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Nutrition reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melaku Tadege EngidawPublic Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.ORCID 0000-0002-1970-5102
Patricia LeePublic Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.
Gelana FekaduSchool of Nursing and Midwifery, Griffith University, Gold Coast, Queensland 4222, Australia.
Prasenjit MondalPublic Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.
Faruk AhmedPublic Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextStakeholders implement nutrition education to prevent and control anemia during pregnancy. Nutrition education during pregnancy can increase the consumption of iron-folic acid (IFA) supplements and encourage behavioral changes. However, there is no comprehensive meta-analysis to determine the effectiveness of this intervention.

objectiveThis review aimed to determine the effect of nutrition education on IFA supplementation (IFAS) compliance, hemoglobin level change, and prevalence of anemia in low- and middle-income countries. DATA SOURCES: The systematic searches on Ovid Medline, Scopus, Embase (Elsevier), Web of Science, Health and Medical Collection (ProQuest), and Google Scholar were conducted until September 11, 2023. The updated searches were performed on November 16, 2023. DATA EXTRACTION: In total, 12 436 records were imported to Covidence. Of these, 9109 records were screened by title and abstract. A total of 112 records were evaluated in full, and 53 articles were ultimately included based on eligibility.

resultsFifty-three peer-reviewed research articles met the inclusion criteria, involving 13 475 pregnant women. Those who received nutrition education during pregnancy were 2.80 times more likely to comply with IFAS (odds ratio = 2.80; 95% CI: 2.04, 3.83; I2 = 66.20%). There was an average increase of 0.88 g/dL (Cohen's d = 0.88; 95% CI: 0.63, 1.13; I2 = 96.17%) in hemoglobin levels among women who received nutrition education. A meta-regression analysis revealed that 61.85% (adjusted R2 = 61.85%) of heterogeneity between standardized mean differences was explained by anemia status, intervention duration, and geographic region. Also, pregnant women in the nutrition education group had a 34% (relative risk = 0.66; 95% CI: 0.54, 0.80, I2 = 86.85%) lower risk of anemia compared with the control group.

conclusionNutrition education during pregnancy improves compliance with IFAS, increases hemoglobin levels, and reduces the risk of anemia. Therefore, it is crucial to enhance the existing nutrition education program to prevent and control anemia during pregnancy. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42023454241.

Indexed as

AnemiaAnemia, Iron-DeficiencyDietary SupplementsFolic AcidHealth EducationIronPatient CompliancePregnancy Complications, HematologicDeveloping CountriesFemaleHemoglobinsHumansPregnancyPrenatal CareFolic AcidHemoglobinsIronanemiahemoglobiniron–folic acid supplementationnutrition educationpregnant women

Identifiers

PMID39545365
PMCPMC12166189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.