Evidence map›Paper›PMID 39545285›Full record

ArticleJournal of the International Neuropsychological Society : JINS2024

The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV.

Laura M Campbell, Christine Fennema-Notestine, Erin E Sundermann, Averi Barrett, Mark W Bondi, Ronald J Ellis, Donald Franklin, Benjamin Gelman, Paul E Gilbert, Igor Grant and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Laura M CampbellUniversity of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9790-1603
Christine Fennema-NotestineUniversity of California San Diego, La Jolla, CA, USA.
Erin E SundermannUniversity of California San Diego, La Jolla, CA, USA.
Averi BarrettUniversity of California San Diego, La Jolla, CA, USA.
Mark W BondiUniversity of California San Diego, La Jolla, CA, USA.
Ronald J EllisUniversity of California San Diego, La Jolla, CA, USA.
Donald FranklinUniversity of California San Diego, La Jolla, CA, USA.
Benjamin GelmanUniversity of Texas Medical Branch, Galveston, TX, USA.
Paul E GilbertSan Diego State University, San Diego, CA, USA.
Igor GrantUniversity of California San Diego, La Jolla, CA, USA.
Robert K HeatonUniversity of California San Diego, La Jolla, CA, USA.
David J MooreUniversity of California San Diego, La Jolla, CA, USA.
Susan MorgelloThe Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scott LetendreUniversity of California San Diego, La Jolla, CA, USA.
Payal B PatelUniversity of Washington, Seattle, WA, USA.
Scott RoeschSan Diego State University, San Diego, CA, USA.
Raeanne C MooreUniversity of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7499-041X

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespanR24MH129166 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RONALD J. ELLIS, Scott L Letendre · 2022 to 2026
$9.9M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Brain Morphology, Inflammation and Episodic Memory Profiles Among Persons Aging with HIVF31AG067869 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAMPBELL, LAURA MICHELLE · 2020 to 2021
$78k
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIA NIH HHS F31 AG067869NIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH107345NIMH NIH HHS R24 MH129166NIMH NIH HHS T32 MH018399
6 · The paper itself

Abstract

objectiveIdentifying persons with HIV (PWH) at increased risk for Alzheimer's disease (AD) is complicated because memory deficits are common in HIV-associated neurocognitive disorders (HAND) and a defining feature of amnestic mild cognitive impairment (aMCI; a precursor to AD). Recognition memory deficits may be useful in differentiating these etiologies. Therefore, neuroimaging correlates of different memory deficits (i.e., recall, recognition) and their longitudinal trajectories in PWH were examined.

designWe examined 92 PWH from the CHARTER Program, ages 45-68, without severe comorbid conditions, who received baseline structural MRI and baseline and longitudinal neuropsychological testing. Linear and logistic regression examined neuroanatomical correlates (i.e., cortical thickness and volumes of regions associated with HAND and/or AD) of memory performance at baseline and multilevel modeling examined neuroanatomical correlates of memory decline (average follow-up = 6.5 years).

resultsAt baseline, thinner pars opercularis cortex was associated with impaired recognition (

conclusionsEpisodic memory was associated with prefrontal structures, and MTL and prefrontal structures did not predict memory decline. There was relative stability in memory over time. Findings suggest that episodic memory is more related to frontal structures, rather than encroaching AD pathology, in middle-aged PWH. Additional research should clarify if recognition is useful clinically to differentiate aMCI and HAND.

Indexed as

Cognitive DysfunctionHIV InfectionsMemory DisordersMemory, EpisodicPrefrontal CortexTemporal LobeAgedFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMental RecallMiddle AgedNeuropsychological TestsRecognition, PsychologyAgingAlzheimer’s diseasecognitionHIV-associated neurocognitive disordersinfectious diseaseneuroimaging

Identifiers

PMID39545285
PMCPMC11735296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.