Evidence map›Paper›PMID 39545092›Full record

ArticleBioengineering & translational medicine2024

Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma.

Lauren Kass, Morrent Thang, Yu Zhang, Cathleen DeVane, Julia Logan, Addis Tessema, Jillian Perry, Shawn Hingtgen

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren KassDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.ORCID https://orcid.org/0000-0003-0784-185X
Morrent ThangDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Yu ZhangDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Cathleen DeVaneDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Julia LoganDepartment of Chemistry, UNC College of Arts and Sciences The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Addis TessemaDepartment of Chemistry, UNC College of Arts and Sciences The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Jillian PerryDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Shawn HingtgenDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Harnessing Continuous Liquid Interface 3D Printing to Improve Tumor-homing Stem Cell Therapy for Post-surgical Brain CancerR01CA269974 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Shawn Hingtgen, Jillian Perry · 2022 to 2026
$2.2M
Multimodal PerkinElmer IVIS-SpectrumCT imaging system for a preclinical imaging core facilityS10OD026951 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YUAN, HONG · 2020 to 2020
$590k
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA269974NIH HHS S10 OD026951
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common primary malignant brain tumor diagnosed in adults, carrying with it an extremely poor prognosis and limited options for effective treatment. Various cell therapies have emerged as promising candidates for GBM treatment but fail in the clinic due to poor tumor trafficking, poor transplantation efficiency, and high systemic toxicity. In this study, we design, characterize, and test a 3D-printed cell delivery platform that can enhance the survival of therapeutic cells implanted in the GBM resection cavity. Using continuous liquid interface production (CLIP) to generate a biocompatible 3D hydrogel, we demonstrate that we can effectively seed neural stem cells (NSCs) onto the surface of the hydrogel, and that the cells can proliferate to high densities when cultured for 14 days

Indexed as

3D printingcell therapyCLIPglioblastomascaffold

Identifiers

PMID39545092
PMCPMC11558199

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.