ArticleGland surgery2024
The differences between unilateral multifocality and bilateral multifocality in papillary thyroid carcinoma: a retrospective cohort study.
Article in Gland surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Unilateral Multifocal Follicular Thyroid Carcinoma with Vascular Invasion and Primary Hepatic Metastasis in a Dog: First Documented Case.Veterinary sciences · 2026Article
- BRAF Mutation Status Determines the Prognostic Value of Tumor Bilaterality in Papillary Thyroid Carcinoma: A Retrospective Cohort Study.International journal of endocrinology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The differences between unilateral multifocality and bilaterality in papillary thyroid carcinoma (PTC) are not fully understood. This study aimed to investigate the differences between unilateral multifocal PTC (UMPTC) and bilateral multifocal PTC (BMPTC). Methods: Retrospective data analysis was done on 503 individuals who underwent complete thyroidectomy for PTC. Patients were classified into subgroups according to the type of multifocality including the UMPTC and the BMPTC. The relationships of demographic and clinicopathological features among these groups were analyzed. Results: The patients were divided into the UMPTC group (n=117) and the BMPTC group (n=386). Among them, the BMPTC group was further divided into the N1-BMPTC group (261 cases with one lesion on each thyroid lobe) and the N2-BMPTC group (125 cases with one or more lesions on one lobe and two or more lesions on the other lobe). The maximum tumor diameter (MTD), in the BMPTC group, N1-BMPTC group, and N2-BMPTC group were larger than that in the UMPTC group. The recurrence rate of the N1-BMPTC group was higher than that of the UMPTC group. There were no significant differences in other clinicopathological characteristics [gender, age, body mass index (BMI), presence of Hashimoto's thyroiditis, presence of thyroid nodules, occurrence of capsular invasion, occurrence of extrathyroidal extension, occurrence of lymph node metastasis, and the American Joint Committee on Cancer (AJCC) staging]. The N1-BMPTC group was associated with lymph node metastasis and tumor recurrence. In addition, the disease-free survival (DFS) rates showed the N1-BMPTC group having the lowest DFS rate among the UMPTC, N1-BMPTC, and N2-BMPTC groups. Conclusions: Patients with N1-BMPTCs have a higher recurrence rate than those with other kinds of multifocal PTC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.