Causal Relationships between Circulating Immune Cell Traits and the Risk of Rheumatoid Arthritis and Osteoarthritis: A Bidirectional Two-Sample Mendelian Randomization Study.

Dujuan Mao, Shan Li, Xiufang Li, Lijuan You, Jiaqi Yu, Yaohua Wu, Quanshui Hao, Heng Du

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Article in Iranian journal of public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Methylation of PRDX3 Expression Alleviate Ferroptosis and Oxidative Stress in Patients with Osteoarthritis Cartilage Injury.Archives of rheumatology · 2025
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8 authors.

Dujuan MaoDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Shan LiDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Xiufang LiDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Lijuan YouDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Jiaqi YuDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Yaohua WuDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Quanshui HaoDepartment of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China.

Heng DuDepartment of Gastrointestinal Surgery, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang, 438000, Hubei, China.

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint disorders with immunological pathogenesis. However, the causal relationships between circulating immune cells and them remain largely unknown. Therefore, we conducted a bidirectional two-sample Mendelian randomization (MR) study to determine their causal relationship. Methods: Genome-wide association study summary statistics were extracted from publicly available databases regarding immune cell phenotypes, RA, and OA. MR analysis was conducted using five MR methods, with inverse-variance-weighted (IVW) as the primary analysis method. False discovery rate correction (FDR) was used to reduce the likelihood of type 1 errors. We also conducted MR-Egger intercept tests to evaluate horizontal pleiotropy. Results: After FDR adjustment of the Conclusion: Our study demonstrates a causal relationship between specific immune cell traits and RA as well as OA, providing further insight into the role of immune cells in the pathogenesis of these disorders.

Indexed as

Causal associationImmune cellsMendelian randomizationOsteoarthritisRheumatoid arthritis

Identifiers

PMID39544856

DOI10.18502/ijph.v53i10.16718

PMCPMC11557758

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