Evidence map›Paper›PMID 39544846›Full record

ArticleAfrican journal of thoracic and critical care medicine2024

The significance of monitoring respiratory sample cultures and polymerase chain reaction tests for detecting bacterial pathogens in severely and critically ill patients with COVID-19.

D Strelkova, V Kuleshov, E Burmistrova, I Sychev, Y Savochkina, D Danilov, S Yatsyshina, E Glushchenko, M Elkina, N Ananicheva and 3 more

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Article in African journal of thoracic and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

D StrelkovaI. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
V KuleshovCity Clinical Hospital named after S. S. Yudin, Moscow, Russian Federation.
E BurmistrovaCity Clinical Hospital named after S. S. Yudin, Moscow, Russian Federation.
I SychevRussian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
Y SavochkinaFederal State Budgetary Institution, Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical and Biological Agency, Moscow, Russian Federation.
D DanilovFederal State Budgetary Institution, Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical and Biological Agency, Moscow, Russian Federation.
S YatsyshinaCentral Research Institute of Epidemiology (CRIE) of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation.
E GlushchenkoFederal State Budgetary Institution, Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical and Biological Agency, Moscow, Russian Federation.
M ElkinaCentral Research Institute of Epidemiology (CRIE) of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation.
N AnanichevaCity Clinical Hospital named after S. S. Yudin, Moscow, Russian Federation.
A YasnevaI. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
S TopolyanskayaI. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
S RachinaI. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bacterial superinfection is one of the most common and potentially lethal complications in severely and critically ill patients with COVID-19. Objectives: To determine the colonisation time frame and the spectrum of potential bacterial pathogens in respiratory samples from patients with severe and critical COVID-19, using routine culture and polymerase chain reaction (PCR) tests. Methods: A prospective observational study was conducted on patients aged ≥18 years with confirmed severe and critical COVID-19 who were admitted to or transferred to the intensive care unit (ICU). Respiratory samples were collected for microbial culture and PCR testing within the first 2 days after ICU admission/transfer, between days 3 and 6, and after 7 days of ICU stay. Results: A total of 82 patients, with a median (interquartile range) age of 74.5 (67.3 - 81.0) years and a median Charlson comorbidity index of 4 (3 - 5), were enrolled in the study. Colonisation with any pathogen was observed in 67% of patients, after a median of 4 (2 - 6) days in the ICU. On days 0 - 2 of the ICU stay, micro-organisms were detected in 18% of patients, with Conclusion: Our study confirms that colonisation of the respiratory tract occurs early in the course of ICU stay. Superinfections are predominantly caused by multidrug-resistant Gram-negative bacteria. Study synopsis:

Indexed as

colonisationCOVID-19PCRpolymerase chain reactionSARS-CoV-2superinfection

Identifiers

PMID39544846
PMCPMC11561391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.