ReviewAmerican journal of translational research2024
Quantitative assessment of the association between TNF-α gene polymorphisms and angina risk.
Review in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
backgroundPrevious investigations into the correlation between tumor necrosis factor-α (TNF-α) gene polymorphism and susceptibility to angina have produced a range of results. This study aims to clarify the potential significance of TNF-α polymorphism as a contributing factor to the onset of angina.
methodsA comprehensive review of all corresponding literature was conducted across several major databases, covering their records from inception through to March 2024. Data were synthesized using meta-analysis techniques.
resultsNotable associations were identified in various genetic comparisons: allele contrast (A vs. G: OR=0.77, 95% CI=0.70-0.86, P<0.001), homozygote comparison (AA vs. GG: OR=3.35, 95% CI=2.51-4.48, P<0.001), heterozygote comparison (GA vs. GG: OR=1.69, 95% CI=1.19-2.40, P=0.003), recessive genetic model (AA vs. GG/GA: OR=2.40, 95% CI=1.91-3.03, P<0.001), and dominant genetic model (AA/GA vs. GG: OR=1.84, 95% CI=1.27-2.65, P=0.001). Furthermore, ethnicity-based subgroup analyzes revealed that these associations were especially significant within the Asian population and unstable angina, with all genetic models demonstrating statistical significance (P<0.05).
conclusionsTNF-α gene is significantly associated with an increased risk of angina, particularly among the Asian population and unstable angina. This finding underscores the importance of considering genetic factors in the assessment and management of angina risk.
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