ArticleAmerican journal of translational research2024
Assessment of frailty status in patients with acute cerebral infarction and their relationship with serum markers.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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- Risk prediction models for frailty in stroke patients: a systematic review and meta-analysis.Frontiers in neurologyPooled it
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5 authors.
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Abstract
objectiveFrailty status is closely related to cerebral infarction, but there is a lack of objective biomarkers to determine frailty status in cerebral infarction patients. This study explores frailty status and frailty-related serum markers in patients with acute cerebral infarction and determines their diagnostic value for frailty.
methodsA total of 146 patients with acute cerebral infarction admitted to Hangzhou Third people's Hospital from January 2021 to December 2023 were enrolled prospectively. The Edmonton scale was used to evaluate the patients in the frailty and non-frailty groups. The clinical frailty scale (CFS) was used to divide frailty patients into mild, moderate, and severe frailty groups, comparing clinical data and levels of serum markers among different groups, and analyzing the risk factors for frailty in cerebral infarction.
resultsAmong the 146 patients, 70 cases (47.9%) were in the frailty group, and 76 cases (52.1%) in the non-frailty group. Compared with patients in the non-frailty group, patients in the frailty group had significantly lower levels of hemoglobin, triglycerides, low-density lipoprotein, and albumin (P<0.05 or 0.01), while levels of C-reactive protein (CRP), D-dimer, and homocysteine (Hcy) were significantly increased (P<0.05 or 0.01). Logistic regression analysis found that the levels of hemoglobin and Hcy were independent risk factors for frailty in acute cerebral infarction patients, with the ROC curve areas of 0.707 and 0.751, respectively. The ROC curve area for predicting frailty by combining hemoglobin and Hcy levels was 0.799.
conclusionThe incidence of frailty in patients with acute cerebral infarction is high, and serum markers of hemoglobin and Hcy have certain value in determining frailty in patients with acute cerebral infarction.
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