ArticleAmerican journal of translational research2024
Serum bisphenol S levels are associated with decreased ovarian reserve function: a single-center study.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis.Pediatric discovery · 2026Article
- Bisphenol A Alternatives in Follicular Fluid: Novel Risk Factors for Ovarian Reserve Dysfunction.ACS omega · 2026Article
- Integrated chemical exposome-metabolome profiling of follicular fluid and associations with fertility outcomes during assisted reproduction.Environment international · 2025Article
- Associations Between Endocrine-Disrupting Chemical Exposure and Fertility Outcomes: A Decade of Human Epidemiological Evidence.Life (Basel, Switzerland) · 2025Review
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4 authors.
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Abstract
objectivesBisphenol A (BPA) is a representative environmental estrogen that is known to impair the function of the female reproductive system by affecting steroid hormones. However, not much research has been done on bisphenol S (BPS), which is an analogue of BPA and has been found in humans.
methodsWe retrospectively studied 152 female volunteers at childbearing age who came to the Shandong Provincial Reproductive Medicine Center between January 2018 and January 2023. Anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E2) were used as indicators of their ovarian reserve function. Enzyme-linked immunosorbent assay (ELISA) was used to quantify the concentration of Bisabolol S in the serum of the enrolled volunteers. Linear regression models and logistic regression models were used to assess the relationship between urinary Bisphenol S levels and ovarian reserve indicators and decrease ovarian reserve (DOR) indicators, respectively. Restricted cubic spline (RCS) models were further used to explore potential non-linear associations.
resultsThe results showed that serum Bisabolol S levels were negatively correlated with AMH and E2 levels and positively correlated with FSH levels. After the volunteers were grouped and analysed according to the DOR diagnostic criteria,the serum BPA content in the DOR group was significantly higher than that in the non-DOR group (P < 0.05). Compared with the non-DOR group, the levels of anti-Müller test tube hormone (AMH) and estrogen (E2) were lower in the DOR group and the level of FSH was higher (P < 0.05). The serum BPS content in the DOR group was negatively correlated with AMH and E2. The concentration of FSH in women in the DOR group increased when the serum BPS content was also increased.
conclusionsSerum BPS is a potential risk factor for ovarian reserve function in women of reproductive age.
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