Evidence map›Paper›PMID 39544743›Full record

ArticleAmerican journal of translational research2024

Jian Zhou, Fanru Zhou, Liu Yang, Haihui Liang, Qinyao Zhu, Fenghua Guo, Xiushan Yin, Jian Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Animals : an open access journal from MDPI · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jian ZhouApplied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology Shenyang 110142, Liaoning, China.
Fanru ZhouApplied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology Shenyang 110142, Liaoning, China.
Liu YangApplied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology Shenyang 110142, Liaoning, China.
Haihui LiangApplied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology Shenyang 110142, Liaoning, China.
Qinyao ZhuApplied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology Shenyang 110142, Liaoning, China.
Fenghua GuoGlabiolus Biotech (Xuzhou) Co., Ltd. Xuzhou 221000, Jiangsu, China.
Xiushan YinApplied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology Shenyang 110142, Liaoning, China.
Jian LiCollege of Pharmaceutical Sciences, Gannan Medical University Ganzhou 341000, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMETHODS AND

resultsIn this study, we investigated the osteogenesis-promoting effects of MOS on human umbilical cord-derived mesenchymal stem cells (HUC-MSCs). Alkaline phosphatase staining, alizarin red staining, and quantitative reverse transcription-PCR demonstrated that MOS promoted the osteogenic differentiation of HUC-MSCs in a concentration-dependent manner. RNA sequencing results showed that the expression of key osteogenic differentiation-related genes, including

conclusionsOverall, the results indicate that MOS can partially promote osteogenic differentiation of HUC-MSCs by regulating the BMP-SMAD signaling pathway. These findings indicate the potential utility of MOS as a therapeutic agent for osteoporosis, particularly in the context of stem cell therapy.

Indexed as

human umbilical cord-derived mesenchymal stem cellsMorinda officinalis saponinsosteogenic differentiationRNA sequencingstem cell therapy

Identifiers

PMID39544743
PMCPMC11558395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.