ArticleInternational journal of clinical and experimental pathology2024
PCSK7, a potential target for the treatment of age-related macular degeneration: inhibition of retinal epithelial cell death.
Article in International journal of clinical and experimental pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Integrating single-cell and bulk RNA-Seq to unravel the molecular mechanisms of airway stenosis.Functional & integrative genomics · 2025Article
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3 authors.
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Abstract
backgroundAge-related macular degeneration (AMD) is a complex disease with a pathophysiology that remains incompletely understood. PCSK7 is closely related to the normal development of ocular tissues; however, the roles and mechanisms of PCSK7 in AMD have yet to be elucidated. Therefore, the purpose of this study was to investigate the specific manifestations of PCSK7 in AMD.
methodsAn AMD cell model was established by using hydrogen peroxide (H
resultsOverexpressing of PCSK7 enhanced the proliferation and inhibited the apoptosis of ARPE-19 cells treated with H
conclusionsPCSK7 might be one of the targets for the treatment of AMD through the regulation of retinal epithelial cell death.
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