ArticleJournal of human reproductive sciences
Utilisation of Oocyte Diameter as a Non-invasive Indicator of Oocyte and Embryo Quality: Investigating Protein Kinase B Protein Expression in Cumulus-Granulosa Cells and Embryo Morphokinetics.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oocyte diameter is crucial for initiating meiosis and supporting the maturation capability, a prerequisite for successful fertilisation and high-quality embryo development. While numerous studies have explored the correlation between oocyte diameter and embryo development capacity in animal models, limited research appears concerning human oocytes. Aim: This study aims to ascertain whether oocyte diameter can serve as a reliable predictor of oocyte and embryo quality, achieved through its correlation with protein kinase B (Akt) protein levels on cumulus-granulosa cells and blastocyst morphokinetics. Setting and Design: Prospective cohort study included cumulus-granulosa cells collected from 228 mature oocytes of 32 infertile women undergoing Statistical Analysis Used: The Kruskal-Wallis test and Chi-square test were used. Results: The study revealed no notable difference in pAkt and Akt protein total in cumulus-granulosa cells among the three groups ( Conclusion: Reflecting on the molecular profile including pAkt, total Akt protein, morphokinetics and anomaly development, it was observed that oocyte diameter does not correlate with its competency and the quality of the resulting embryo. In addition, oocytes with a diameter below 105.95 µm may have an equal potential to develop into top-quality embryos.
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