Evidence map›Paper›PMID 39544563›Full record

ArticleCureus2024

Rituximab-Associated Acute Ischemic Stroke in a Patient With Primary Angiitis of the Central Nervous System.

Furkan Asan, Zeynep Esin Sayar, Kagan Gokdeniz Karadeniz, Bengi Gul Turk, Sabahattin Saip

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Furkan AsanDepartment of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, TUR.
Zeynep Esin SayarDepartment of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, TUR.
Kagan Gokdeniz KaradenizDepartment of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, TUR.
Bengi Gul TurkDepartment of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, TUR.
Sabahattin SaipDepartment of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, TUR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During or after rituximab treatment, various serious side effects may occur. Cerebrovascular diseases are relatively limited among these side effects, and whether they are contingent on rituximab treatment is unclear. This case report highlights an unusual and severe event after rituximab treatment. Our patient was a 32-year-old female diagnosed with primary angiitis of the central nervous system (PACNS). Despite meticulous management with azathioprine, the patient's condition exhibited persistent ischemic activity, necessitating a therapeutic shift to rituximab. Regrettably, very soon after the initial rituximab infusion, a substantial acute ischemic stroke took place in the right cerebral hemisphere. We have interpreted that the significant stenosis in the right internal carotid artery, which had developed due to PACNS, may pose a risk for the development of acute ischemia in our patient after rituximab treatment. In conclusion, careful evaluation of rituximab treatment may be appropriate in patients with serious stenosis of intracranial major arteries.

Indexed as

acute ischemiacentral nervous system vasculitiscerebrovascular diseaserituximabrituximab-induced strokevasospasm

Identifiers

PMID39544563
PMCPMC11560401

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.