Evidence map›Paper›PMID 39544498›Full record

ArticlePNAS nexus2024

Piezo1-mediated mechanotransduction enhances macrophage oxidized low-density lipoprotein uptake and atherogenesis.

Hamza Atcha, Daanish Kulkarni, Vijaykumar S Meli, Praveen Krishna Veerasubramanian, Yuchun Wang, Michael D Cahalan, Medha M Pathak, Wendy F Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. NaFrontiers in chemistry · 2026
    Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hamza AtchaDepartment of Bioengineering, University of California, San Diego, La Jolla 92093, USA.ORCID https://orcid.org/0000-0002-7590-8342
Daanish KulkarniDepartment of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.
Vijaykumar S MeliDepartment of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.
Praveen Krishna VeerasubramanianDepartment of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.ORCID https://orcid.org/0000-0001-8204-088X
Yuchun WangDepartment of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.ORCID https://orcid.org/0000-0003-4949-2432
Michael D CahalanDepartment of Physiology and Biophysics, University of California Irvine, Irvine 92697, USA.ORCID https://orcid.org/0000-0002-4987-2526
Medha M PathakDepartment of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.ORCID https://orcid.org/0000-0002-6518-3085
Wendy F LiuDepartment of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.ORCID https://orcid.org/0000-0002-8904-7643

Funding

Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2007 to 2016
$25.1M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Molecular Mechanisms of lon Channels in T LymphocytesR01NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1985 to 2022
$7.0M
Biophysical regulation of macrophage functionR01AI151301 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2020 to 2024
$2.9M
Building the brain: How mechanical forces shape human neural developmentDP2AT010376 · NCCIH · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2020
$2.9M
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER01AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2020
$2.5M
Piezo1 in neural stem cell mechano-regulationR01NS109810 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2022
$2.2M
Multiphoton Microscope for Cardiovascular and Tissue EngineeringS10OD025064 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2019 to 2019
$595k
Epigenetic regulation of macrophage response to biomaterial implantsR21EB027840 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOWNING, TIMOTHY LAMONT, LIU, WENDY · 2019 to 2020
$398k
Mechanical regulation of skin repair and regenerationR21AR077288 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2020 to 2021
$375k
NCCIH NIH HHS DP2 AT010376NHLBI NIH HHS T32 HL007444NIAID NIH HHS R01 AI121945NIAID NIH HHS R01 AI151301NIAMS NIH HHS R21 AR077288NIBIB NIH HHS R21 EB027840NIGMS NIH HHS P50 GM076516NIH HHS S10 OD025064NINDS NIH HHS R01 NS014609NINDS NIH HHS R01 NS109810
6 · The paper itself

Abstract

Macrophages in the vascular wall ingest and clear lipids, but abundant lipid accumulation leads to foam cell formation and atherosclerosis, a pathological condition often characterized by tissue stiffening. While the role of biochemical stimuli in the modulation of macrophage function is well studied, the role of biophysical cues and the molecules involved in mechanosensation are less well understood. Here, we use genetic and pharmacological tools to show extracellular oxidized low-density lipoproteins (oxLDLs) stimulate Ca

Indexed as

atherosclerosisfoam cellmacrophagemechanotransductionPiezo1

Identifiers

PMID39544498
PMCPMC11563038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.